Adult-onset type 1 diabetes patients display decreased IGRP-specific Tr1 cells in blood

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Daisuke ChujoHideki Ueno

Abstract

The breakdown of immune tolerance against islet antigens causes type 1 diabetes (T1D). The antigens associated with adult-onset T1D (AT1D) remain largely undefined. It is possible that AT1D patients display a unique type of CD4(+) T cells specific for a certain islet antigen. Here we analyzed the cytokine production profiles of CD4(+) helper T (Th) cells that are specific for three islet antigens; GAD65, preproinsulin, and IGRP in patients with AT1D, juvenile-onset T1D (JT1D), and age-, gender- and human leukocyte antigen (HLA)-matched control adults. While IGRP-specific Th cells in AT1D patients were dominantly Th1 cells, IGRP-specific Th cells in control adults and JT1D patients were dominantly Th2 and T regulatory type 1 (Tr1) cells. Notably, the frequency of IGRP-specific Tr1 cells was significantly lower in AT1D patients than in control adults and JT1D patients. In conclusion, our study suggests that IGRP-specific Th cells play a unique pathogenic role in AT1D.

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Citations

Jun 4, 2016·Journal of Autoimmunity·Emma E Hamilton-WilliamsRaymond J Steptoe
Jun 2, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karen CerosalettiPeter S Linsley
Jan 23, 2019·Journal of Cellular Physiology·Xi JiaJin-An Zhang
Jul 12, 2020·The Journal of Clinical Endocrinology and Metabolism·Daisuke ChujoMasayuki Shimoda
Sep 13, 2017·Proceedings of the National Academy of Sciences of the United States of America·Hua YuRichard A Flavell
Aug 28, 2020·Frontiers in Immunology·Tiantian YueCong-Yi Wang

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