Adult-onset type 1 diabetes: Predictors of glycaemic control

Endocrinology, Diabetes & Metabolism
Dan HesseMartin Ridderstråle

Abstract

Knowledge about adult-onset (AO) type 1 diabetes remains insufficient. We sought to characterize the initial 5 years of AO type 1 diabetes and hypothesized that initial factors predictive of subsequent glycaemic control might exist. A retrospective cohort study based on electronic medical records of 280 subjects with newly diagnosed AO type 1 diabetes (>18 years of age, excluding secondary and latent autoimmune diabetes) with available data for the initial 5-year treatment. Characteristics at diagnosis: 61% men, mean age 37 ± 12 years, BMI 23 ± 3.3 (kg/m2), systolic/diastolic blood pressure: 123 ± 15/76 ± 9 mm Hg and LDL cholesterol: 2.9 ± 0.9 mmol/L. HbA1c decreased from 106 mmol/mol (11.8%) at diagnosis to 52 mmol/mol (6.9%) at 6 months and then increased gradually to 67 mmol/mol (8.3%) after 5 years. Strict glycaemic control (<53 mmol/mol (7%)) was achieved by 66% within 6-9 months and 30% after 5 years. Comparing patients with and without strict glycaemic control after 5 years revealed no differences in HbA1c, C-peptide or any other diabetes-related parameter at the time of diagnosis. However, reaching strict control within 6-9 months after diagnosis was strongly associated with remaining in strict control after 5 years (OR...Continue Reading

References

Apr 30, 2002·Diabetes·Jinko GrahamUNKNOWN Swedish Childhood Diabetes Study Group
Jan 21, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·E LaugesenUNKNOWN Danish Diabetes Academy Workshop and Workshop Speakers
Sep 22, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·M S B Huda, G A Hitman
Sep 29, 2015·Current Diabetes Reports·Jackie SturtKate McCarthy
Jul 28, 2016·Current Diabetes Reports·Jakob Appel ØstergaardR David Leslie

❮ Previous
Next ❯

Software Mentioned

SAS Enterprise Guide

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.