Adult Stem Cell-Based Strategies for Peripheral Nerve Regeneration

Advances in Experimental Medicine and Biology
Metzere Bierlein De la RosaDonald S Sakaguchi

Abstract

Peripheral nerve injuries (PNI) occur as the result of sudden trauma and can lead to life-long disability, reduced quality of life, and heavy economic and social burdens. Although the peripheral nervous system (PNS) has the intrinsic capacity to regenerate and regrow axons to a certain extent, current treatments frequently show incomplete recovery with poor functional outcomes, particularly for large PNI. Many surgical procedures are available to halt the propagation of nerve damage, and the choice of a procedure depends on the extent of the injury. In particular, recovery from large PNI gaps is difficult to achieve without any therapeutic intervention or some form of tissue/cell-based therapy. Autologous nerve grafting, considered the "gold standard" is often implemented for treatment of gap formation type PNI. Although these surgical procedures provide many benefits, there are still considerable limitations associated with such procedures as donor site morbidity, neuroma formation, fascicle mismatch, and scarring. To overcome such restrictions, researchers have explored various avenues to improve post-surgical outcomes. The most commonly studied methods include: cell transplantation, growth factor delivery to stimulate regene...Continue Reading

Citations

Nov 15, 2019·Muscle & Nerve·Carrie A KubiakStephen W P Kemp
Apr 4, 2019·Molecular Neurobiology·Eliana Baez-JuradoGeorge E Barreto
Nov 10, 2020·Tissue Engineering. Part a·Meer N AhmedFatima N Syed-Picard
Jan 13, 2021·Neural Regeneration Research·Sara SaffariAlexander Y Shin
Apr 6, 2021·Neural Regeneration Research·Rui-Cheng ZhangDe-Qin Geng
Aug 18, 2020·Plastic and Reconstructive Surgery. Global Open·Riccardo SchweizerVijay S Gorantla

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.