Adult stem cell theory of the multi-stage, multi-mechanism theory of carcinogenesis: role of inflammation on the promotion of initiated stem cells

Contributions to Microbiology
J E Trosko, Mei-Hui Tai

Abstract

Inflammation, induced by microbial agents, radiation, endogenous or exogenous chemicals, has been associated with chronic diseases, including cancer. Since carcinogenesis has been characterized as consisting of the 'initiation', 'promotion' and 'progression' phases, the inflammatory process could affect any or all three phases. The stem cell theory of carcinogenesis has been given a revival, in that isolated human adult stem cells have been isolated and shown to be 'targets' for neoplastic transformation. Oct4, a transcription factor, has been associated with adult stem cells, as well as their immortalized and tumorigenic derivatives, but not with the normal differentiated daughters. These data are consistent with the stem cell theory of carcinogenesis. In addition, Gap Junctional Intercellular Communication (GJIC) seems to play a major role in cell growth. Inhibition of GJIC by non-genotoxic chemicals or various oncogenes seems to be the mechanism for the tumor promotion and progression phases of carcinogenesis. Many of the toxins, synthetic non-genotoxicants, and endogenous inflammatory factors have been shown to inhibit GJIC and act as tumor promoters. The inhibition of GJIC might be the mechanism by which the inflammatory p...Continue Reading

Citations

Feb 13, 2008·Molecular and Cellular Biology·Margaret P QuinlanJeffrey Settleman
Oct 10, 2013·Expert Opinion on Drug Metabolism & Toxicology·David Canovas-JordaSusanne Bremer
Oct 7, 2011·British Journal of Neurosurgery·Siyi WanggouQiaoyu Li
Jul 16, 2015·Stem Cells and Development·Luca PersanoFrancesca Pistollato
Feb 22, 2017·Journal of Cell Communication and Signaling·James E Trosko, Heinz-Josef Lenz
Oct 5, 2010·International Journal of Toxicology·Peter J BugelskiJacques Descotes
Dec 3, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·James E Trosko
Jun 5, 2007·Journal of Cellular Biochemistry·A GrazianoG Pirozzi
Jun 23, 2007·Molecular Carcinogenesis·Thaned KangsamaksinRebecca J Morris
Feb 21, 2008·American Journal of Nephrology·Sandeep Gupta, Mark E Rosenberg
Apr 22, 2008·Stem Cell Reviews·James E Trosko
Oct 9, 2007·The Cancer Journal·Madhuri Kakarala, Max S Wicha
Mar 25, 2009·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Albrecht Reichle, Thomas Vogt
Mar 3, 2009·Annals of the New York Academy of Sciences·Letizia CocciadiferroGiuseppe Carruba
Mar 15, 2016·Nature Reviews. Genetics·Andrew P FeinbergAnita Göndör
Apr 6, 2011·Molecular Carcinogenesis·Emma J DaviesAlan R Clarke
Jun 25, 2015·Carcinogenesis·Kannan Badri NarayananHyun Ho Park
Oct 1, 2019·Dose-response : a Publication of International Hormesis Society·James E Trosko
Jan 1, 2008·Gene Regulation and Systems Biology·Simon Rosenfeld, Izet Kapetanovic
Mar 16, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M Mimeault, S K Batra
Dec 27, 2011·Preventive Medicine·Se-Ran YangKyung-Sun Kang

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