Adult Stem Cell Therapies for Wound Healing: Biomaterials and Computational Models

Frontiers in Bioengineering and Biotechnology
Daniele Tartarini, Elisa Mele

Abstract

The increased incidence of diabetes and tumors, associated with global demographic issues (aging and life styles), has pointed out the importance to develop new strategies for the effective management of skin wounds. Individuals affected by these diseases are in fact highly exposed to the risk of delayed healing of the injured tissue that typically leads to a pathological inflammatory state and consequently to chronic wounds. Therapies based on stem cells (SCs) have been proposed for the treatment of these wounds, thanks to the ability of SCs to self-renew and specifically differentiate in response to the target bimolecular environment. Here, we discuss how advanced biomedical devices can be developed by combining SCs with properly engineered biomaterials and computational models. Examples include composite skin substitutes and bioactive dressings with controlled porosity and surface topography for controlling the infiltration and differentiation of the cells. In this scenario, mathematical frameworks for the simulation of cell population growth can provide support for the design of bioconstructs, reducing the need of expensive, time-consuming, and ethically controversial animal experimentation.

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Citations

May 19, 2017·Nanomedicine·Shixuan ChenJingwei Xie
Dec 5, 2017·Annals of Dermatology·Christine M ProdingerMartin Laimer
Sep 18, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Luminita LabuscaNicoleta Lupu
Aug 18, 2020·SN Applied Sciences·L E WadkinN G Parker
Nov 9, 2018·Frontiers in Bioengineering and Biotechnology·Anna DenchaiElisa Mele
Jul 10, 2019·Materials·Mara Madalina MihaiAlina Maria Holban
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Mar 12, 2020·Frontiers in Bioengineering and Biotechnology·Spase Stojanov, Aleš Berlec
May 21, 2021·Frontiers in Bioengineering and Biotechnology·Dharshan SivarajGeoffrey C Gurtner
Feb 19, 2019·ACS Biomaterials Science & Engineering·Nicholas J KaiserKareen L K Coulombe
Aug 21, 2021·Physical Review. E·G M CarvalhoP Patrício

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Software Mentioned

Abaqus
CHASTE
COmplex PAthway SImulator ( COPASI )
FLAME
CompuCell3D
FEniCS
ANSYS
Flexible Large - scale Agent Modeling Environment ( FLAME )

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