Adult stem cells and tissue engineering strategies for salivary gland regeneration: a review

Biomaterials Research
Chankee YooHo-Wook Jun

Abstract

Saliva is an important compound produced by the salivary glands and performs numerous functions. Hyposalivation (dry mouth syndrome) is a deleterious condition often resulting from radiotherapy for patients with head and neck cancer, Sjogren's Syndrome, or as a side effect of certain medications. Hyposalivation negatively affects speaking, mastication, and swallowing in afflicted patients, greatly reducing their quality of life. Current treatments for this pathology include modifying lifestyle, synthetic saliva supplementation, and the utilization of salivary gland stimulants and sialagogues. However, many of these treatments do not address the underlying issues and others are pervaded by numerous side effects. In order to address the shortcomings related to current treatment modalities, many groups have diverted their attention to utilizing tissue engineering and regenerative medicine approaches. Tissue engineering is defined as the application of life sciences and materials engineering toward the development of tissue substitutes that are capable of mimicking the structure and function of their natural analogues within the body. The general underlying strategy behind the development of tissue engineered organ substitutes is t...Continue Reading

Citations

Apr 8, 2020·Regenerative Medicine·Erum KhanZohaib Khurshid
Aug 5, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Nicholas G FischerConrado Aparicio
Oct 21, 2016·Tissue Engineering. Part C, Methods·Lauren SfakisAlexander Khmaladze
Mar 30, 2018·International Journal of Molecular Sciences·Lauren SfakisJames Castracane
Jul 11, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Chin-Hui SuShih-Han Hung
Jan 13, 2017·PloS One·Vinay Kumar AakaluSubramanian Krishnakumar
Feb 9, 2017·Stem Cells Translational Medicine·Padma Pradeepa SrinivasanSwati Pradhan-Bhatt
Feb 15, 2019·International Journal of Molecular Sciences·Mahmoud MonaSeunghee Cha
Feb 16, 2016·Biomaterials Science·Tugba OzdemirXinqiao Jia
Dec 3, 2020·International Journal of Molecular Sciences·Mahmoud MonaSeunghee Cha

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Methods Mentioned

BETA
cesarean section
transfection

Software Mentioned

Encaptra

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