PMID: 7031654Oct 1, 1981Paper

Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera

Proceedings of the National Academy of Sciences of the United States of America
Y HinumaI Miyoshi

Abstract

Indirect immunofluorescence of certain human sera demonstrated an antigen(s) in the cytoplasm of 1--5% of the cells of a T-cell line, MT-1, from a patient with adult T-cell leukemia (ATL), which is endemic in southwestern Japan. The antigen was not detected in other human lymphoid cell lines, including six T-cell lines, seven B-cell lines, and four non-T non-B cell lines. The antigen did not show cross antigenicity with that of herpesviruses, including Epstein--Barr virus, herpes simplex virus, cytomegalovirus, varicella-zoster virus, herpesvirus saimiri, and Marek disease virus. The proportion of antigen-bearing cells was increased by a factor of approximately 5 on culture in the presence of 5-iodo-2'-deoxyuridine. Antibodies against the antigen in MT-1 cells were found in all 44 patients with ATL examined and in 32 of 40 patients with malignant T-cell lymphomas (most of them had diseases similar to ATL except that leukemic cells were not found in the peripheral blood). The antibodies were also detected in 26% of the healthy adults examined from ATL-endemic areas but in only a few of those examined from ATL-non-endemic areas. On electron microscopy, extracellular type C virus particles were detected in pelleted MT-1 cells cult...Continue Reading

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Citations

Sep 1, 1996·American Journal of Hematology·H TaguchiI Miyoshi
Oct 1, 1996·American Journal of Hematology·T KubotaI Miyoshi
Oct 23, 1998·Journal of Medical Virology·M MillerB Shohat
Sep 1, 1990·American Journal of Hematology·I KubonishiI Miyoshi
Jun 1, 1991·Arthritis and Rheumatism·M Nishikai, A Sato
Nov 1, 1993·Arthritis and Rheumatism·H YamamotoY Iwakura
May 7, 2002·International Journal of Cancer. Journal International Du Cancer·Naoki MoriNaoki Yamamoto
May 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M L LabatP Chandra
Jan 1, 1993·Journal of Medical Virology·I YamadeY Yoshida
Dec 1, 1990·Journal of Neuroscience Research·S U Kim
Sep 1, 1992·European Journal of Epidemiology·A R ZanettiF Mazzotta
Feb 1, 1995·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·H KawaiS Saito
Jan 1, 1985·Skeletal Radiology·T OhuchidaK Matsuura
Jan 1, 1984·European Journal of Pediatrics·C R Bartram
Jan 1, 1983·Virchows Archiv. A, Pathological Anatomy and Histopathology·H UenoK Kikuchi
Mar 1, 1985·Journal of Clinical Immunology·H Tsuda, K Takatsuki

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