May 1, 1989

Adult T-cell leukemia (chronic type) with unusual surface phenotype CD 4+5+8-, Leu 7+ at acute crisis

[Rinshō ketsueki] The Japanese journal of clinical hematology
T MorikawaY Yamada

Abstract

Chronic adult T-cell leukemia with surface phenotype CD 4+5+8-, Leu 7+ at acute crisis was presented. A 43-year-old female visited our hospital complaining of generalized lymphadenopathy and skin rash in December, 1973. Peripheral blood picture and histological findings of skin led to the diagnosis of malignant lymphoma (leukemic type). Intermittent chemotherapy kept white blood cell count less than 25,000/microliters for more than 9 years. In January, 1983, abnormal lymphocytes began to increase and reached 100,000/microliters or over in a few months. Surface marker study showed their phenotype as CD 4+5+8-, Leu 7+ and anti-ATLA antibody was positive in the patient, her son and her daughter. Intensive chemotherapy was ineffective and she died in August, 1983. Histological diagnosis of lymph-nodes on autopsy was malignant lymphoma (diffuse, small cell type). This case is considered unusual in both clinical course and surface phenotype of its leukemic cells.

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Mentioned in this Paper

CD4 Antigens
Peripheral Blood
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Autopsy
T6 Antigens
CD8 Antigens
Adult T-Cell Lymphoma/Leukemia
White Blood Cell Count Procedure
CD57 Antigens
Hairy Cell Leukemia

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