Adult T cell leukemia lymphoma

Frontiers in Bioscience : a Journal and Virtual Library
Lee Ratner

Abstract

Adult T cell leukemia lymphoma (ATLL) is a CD4+ lymphoproliferative malignancy resulting from human T-cell leukemia virus type 1 (HTLV-1) infection. It includes differing clinical forms classified as smoldering, chronic, lymphomatous, and acute ATLL. The Tax protein of HTLV-1 has been implicated as a viral oncoprotein which enhances virus replication and alters cellular gene expression, including activation of nuclear factor kappa B (NF kB), to result in lymphoid transformation. Chemotherapy for ATLL has had limited efficacy with median survivals of about 1 yr. Antiviral therapy employing zidovudine and interferon has shown promising results, as have antibody-based therapies to the interleukin 2 (IL2) receptor. Novel approaches employ a combination of chemo/antiretroviral therapy, hematopoietic stem cell transplantation, or inhibitors of NF kB activation.

References

Sep 1, 1987·The Journal of Clinical Investigation·Y WanoW C Greene
Jun 29, 1995·The New England Journal of Medicine·P S GillS Allen
Jun 29, 1995·The New England Journal of Medicine·O HermineF Dreyfus
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·W J GrossmanL Ratner
Oct 1, 1995·Internal Medicine·K Takatsuki
Jan 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·A Bazarbachi, O Hermine
Feb 23, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·H DegaV Leblond
Mar 9, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T A Waldmann
Nov 28, 2000·Japanese Journal of Cancer Research : Gann·T KohnoT Matsuyama
Mar 13, 2001·Annual Review of Immunology·M Yoshida
Dec 1, 2001·The Journal of Biological Chemistry·Takefumi KasaiKuan-Teh Jeang
Mar 7, 2002·Journal of Virological Methods·Axelle DehéeJean Claude Nicolas
Jul 31, 2002·Transfusion·Rigmor ThorstenssonSören Andersson
Aug 16, 2002·Medical Oncology·Claire E DeardenDaniel Catovsky
Jan 11, 2003·The Hematology Journal : the Official Journal of the European Haematology Association·Olivier HermineUNKNOWN French ATL therapy group
Jan 25, 2003·British Journal of Haematology·Masahiro KamiMasaharu Kasai
Feb 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Meili ZhangThomas A Waldmann
Mar 12, 2003·International Journal of Hematology·Kunihiro TsukasakiUNKNOWN Lymphoma Study Group of the Japan Clinical Oncology Group

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Citations

Mar 2, 2011·Bone Marrow Transplantation·M JabbourA S Al-Homsi
Oct 28, 2010·AIDS Research and Human Retroviruses·Rodrigo HaddadSimone Kashima
Aug 12, 2005·Current Opinion in Oncology·Lee Ratner
Feb 11, 2009·PloS One·Lee RatnerUNKNOWN AIDS Malignancy Consortium
Aug 18, 2005·Immunologic Research·Lee Ratner
Apr 9, 2010·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Kara L Menzies, Lyndon Jones
Feb 25, 2010·Leukemia & Lymphoma·Mohammad Reza KeramatiHossein Ayatollahi
Feb 1, 2011·Journal of Virological Methods·Rodrigo HaddadDimas Tadeu Covas
Apr 22, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Despoina BrasinikaYiannis F Missirlis
Mar 20, 2015·Current Infectious Disease Reports·Abelardo Q-C Araujo
Mar 10, 2005·International Journal of Cancer. Journal International Du Cancer·Laura WatersMark Bower
Feb 23, 2019·Blood Advances·Abigail M Druck Shudofsky, Chou-Zen Giam
Dec 25, 2019·Journal of Bone Oncology·Nicole A KohartThomas J Rosol

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