Adult thyroid cancer after head and neck irradiation in infancy and childhood.

Annals of Internal Medicine
F O BeckerR Eisenstein

Abstract

We report the surgical-pathologic findings in 15 adults who had a history of irradiation of the head and neck in childhood. These patients we selected for thyroid surgery because of a "cold" area or areas detected on 99mTc thyroid scan, with or without palpable thyroid abnormalities. Eight of the fifteen patients had thyroid cancer, and 3 had atypical adenomas. We found multiple lesions in 12 patients. Macroscopic and microscopic malignancy in a location different from the cold area or areas occurred in 5 of the 8 cancer patients. In vitro of these findings, we recommend that adults who received irradiation to the head and neck in childhood and who have been found to have an abnormal thyroid scan or thyroid examination, or both, have a total thyroidectomy...

Citations

Jul 1, 1992·Head & Neck·V P KhatriW A Harada
Aug 5, 1976·The New England Journal of Medicine
Feb 1, 1977·Annals of Surgery·M A Block
Dec 1, 1978·The Australian and New Zealand Journal of Surgery·O H Beahrs
Jun 1, 1992·Acta Pathologica Japonica·Y MizukamiF Matsubara
Jan 1, 1980·Auris, Nasus, Larynx·Y SakakuraY Miyoshi
Dec 1, 1980·Journal of the American Academy of Dermatology·H Goldschmidt, W K Sherwin
Oct 1, 1982·American Journal of Surgery·R M ClarkN J Laperriere
Mar 1, 1994·Survey of Ophthalmology·B G HaikB P Pechous
Feb 1, 1983·The American Journal of Medicine·M M KaplanM J Sack
Apr 16, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Uchechukwu C Megwalu, Edward J Shin
Nov 1, 1985·Head & Neck Surgery·L F De Keyser, A J Van Herle
Jan 1, 1980·Journal of Surgical Oncology·M S RazackK L Parthasarathy
Sep 1, 1989·Veterinary Pathology·P J HaleyW C Griffith
Feb 1, 1985·Journal of Surgical Oncology·R L SegalD K Sirota

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.