PMID: 9660110Jul 11, 1998Paper

Adult treatment with haloperidol increases dentate granule cell proliferation in the gerbil hippocampus

Journal of Neural Transmission
R R DawirsG Teuchert-Noodt

Abstract

Male gerbils were bred and reared grouped under enriched semi-natural environmental conditions. The objective of the present study was to examine the influence of an acute treatment with the neuroleptic haloperidol on adult granule cell neurogenesis in the hippocampus. For that purpose, at the age of postnatal day 90 adult animals received 4 challenges of either haloperidol (5 mg/kg, i.p.) or saline. Proliferation of granule cells was identified by in-vivo labeling with 5-bromo-2'-desoxyuridine (BrdU) which was applied 1 hour after the final dose of haloperidol. BrdU-labeled granule cell nuclei were identified in consecutive horizontal slices along the mid-septotemporal axis of the hippocampus and light-microscopically quantified 7 days after the BrdU-labeling. It was found that in both saline- and haloperidol-treated animals there was a highly significant spatial septotemporal gradient in granular cell proliferation with numbers of BrdU-labeled cells gradually declining from the septal towards the temporal pole. The acute treatment with haloperidol stimulated granule cell proliferation by about 75% and the septotemporal gradient of mitotic activity became significantly enhanced. The present results are discussed with regard to...Continue Reading

Citations

Jul 12, 2002·Journal of Neuroscience Research·Chandramohan G WakadeFung-Chow Chiu
May 1, 2007·European Archives of Psychiatry and Clinical Neuroscience·Andreas ReifKlaus-Peter Lesch
Jul 7, 2009·European Archives of Psychiatry and Clinical Neuroscience·Gerburg KeilhoffAxel Becker
Nov 6, 2010·Archives of Pharmacal Research·Kyung-Ok Cho, Seong Yun Kim
Feb 28, 2003·Neuroscience·R HashimotoD-M Chuang
Oct 29, 2002·Brain, Behavior, and Immunity·Barry L Jacobs
Dec 11, 1999·Schizophrenia Research·P J Harrison
Aug 6, 2002·Nature Medicine·Michelle L MonjeTheo D Palmer
Jun 15, 2004·Nature Neuroscience·Günter U HöglingerEtienne C Hirsch
Dec 14, 2004·Harvard Review of Psychiatry·Dost Ongür, Stephan Heckers
Apr 3, 2008·Current Opinion in Psychiatry·Gerd KempermannKlaus Fabel
Jul 24, 2010·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Jianqin NiuLan Xiao
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·D Chichung LieFred H Gage
May 1, 2004·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Hisamitsu Ujihara
Jun 1, 2009·Journal of Toxicologic Pathology·Xi Jun He, Hiroyuki Nakayama
Aug 19, 2007·CNS Drugs·Samuel S Newton, Ronald S Duman
Dec 4, 2001·Acta Psychiatrica Scandinavica. Supplementum·R R Dawirs, G Teuchert-Noodt
May 30, 2013·Development·Daniel A BergAndrás Simon
Jul 7, 2012·Cellular and Molecular Life Sciences : CMLS·Franz MarxreiterJürgen Winkler
Apr 26, 2006·Expert Opinion on Pharmacotherapy·Michael KrebsMartin Schaefer
Sep 30, 2006·Annals of Medicine·Benjamin S PickardWalter J Muir
Oct 17, 2013·Journal of Neuropathology and Experimental Neurology·Ludmyla KandrataviciusJoao Pereira Leite
Jan 19, 2010·Experimental Neurology·June-Hee Park, Grigori Enikolopov
Nov 14, 2006·Medical Hypotheses·Vikas Dhikav, Kuljeet Singh Anand
Jul 20, 2005·The European Journal of Neuroscience·Konrad LehmannGertraud Teuchert-Noodt
Feb 14, 2008·The Journal of Comparative Neurology·Hung-Teh KaoBarbara Porton
May 8, 2008·The Journal of Comparative Neurology·Khushdev K ThindPaul S Buckmaster

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here