Advance of autophagy in chronic kidney diseases

Renal Failure
Xu DengAihua Zhang

Abstract

Autophagy, a highly conserved mechanism for cell survival, emerges as an important pathway in many biological processes and diseases conditions. Studies of cultured renal cells, human kidney tissues and experimental animal models implicate that autophagy regulation is the critical aspects in chronic kidney diseases (CKD). Here, we summarize the current studies on the role of autophagy in CKD. Unveiling the precise regulation mechanism of autophagy in CKD is essential for developing potential prevention, diagnostic and therapeutic targets of these sticky clinical challenges.

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Related Concepts

Programmed Cell Death, Type II
Kidney
Signal Transduction
Chronic Kidney Insufficiency
Autophagy
Cell Survival
Prophylactic Treatment
Epithelial Cell of Renal Tubule
Regulation of Biological Process
Chronic Kidney Diseases

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