PMID: 7091041Apr 1, 1982Paper

Advanced breast cancer with bone-only metastases: a chemotherapeutically responsive pattern of metastases

American Journal of Clinical Oncology
R V SmalleyL S Malmud


Twenty-one patients, presenting with metastases only to bone from a primary adenocarcinoma of the breast having previously undergone mastectomy, tolerated aggressive cytotoxic chemotherapy (CAF--cyclophosphamide 500 mg/m2, Adriamycin 50 mg/m2, 5-fluorouracil 500 mg/m2 q 3 weeks) without significant clinical morbidity. Sixteen of the 21 achieved total clinical symptomatic improvement (pain, performance status). Eleven of these 16 patients tolerated and received between 75% and 100% of the original prescribed dose every 3 weeks, completing a total cumulative course dose of 450 mg/m2 of Adriamycin within 36 weeks, and remained clinically free of disease for an average of 26 months despite cessation of therapy. Their median survival is greater than 3 1/2 years. Those patients tolerating and receiving a dose of 50% or less developed early progression and had a relatively short survival. In general, patients with metastatic disease limited to bone have a relatively good prognosis and are tolerant of and benefit from aggressive cytotoxic therapy. In these patients an excellent clinical response can be achieved with a prolonged disease-free treatment-free period of life.


Aug 25, 2009·Breast Cancer Research and Treatment·Rinat YerushalmiKaren Gelmon
Jun 1, 2000·Breast Cancer Research and Treatment·E F SolomayerG Bastert
Jul 22, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R LargillierE Chamorey
Jan 1, 1995·Cancer Investigation·L VahdatJ Crown
Sep 1, 1986·The American Journal of Medicine·M M SherryJ D Hainsworth
Jun 15, 1983·Cancer·I C Henderson
Nov 30, 1993·Annals of the New York Academy of Sciences·J CrownT Gilewski
Mar 17, 1999·Clinical Orthopaedics and Related Research·L G JenisH S An

Related Concepts

Carcinoma, Cribriform
Antineoplastic Agents
Malignant Bone Neoplasm
Mammary Neoplasms, Human
Cyclophosphamide, (S)-Isomer
Drug Administration Schedule
5-FU medac

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