Advanced cardiac morphogenesis does not require heart tube fusion

Science
Shanru LiEdward E Morrisey

Abstract

The bilateral cardiac mesoderm migrates from the lateral region of the embryo to the ventral midline, where it fuses to form the primitive heart tube. It is generally accepted that migration and fusion are essential for subsequent stages of cardiac morphogenesis. We present evidence that, in Foxp4 mutant embryonic mice, each bilateral heart-forming region is capable of developing into a highly differentiated four-chambered mammalian heart in the absence of midline fusion. These data demonstrate that left-right chamber specification, cardiac looping, septation, cardiac myocyte differentiation, and endocardial cushion formation are preprogrammed in the precardiac mesoderm and do not require midline positional identity or heart tube fusion.

References

May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·R KramerL E Theill
Jun 4, 1999·Seminars in Cell & Developmental Biology·D Yelon, D Y Stainier
Nov 5, 1999·Developmental Biology·J AlexanderD Y Stainier
Dec 2, 1999·Genes & Development·J F ReiterD Y Stainier
Mar 29, 2000·The Anatomical Record·D SedmeraR H Anderson
Sep 23, 2000·Nature·D Srivastava, E N Olson
Jul 27, 2001·American Journal of Medical Genetics·B W Bisgrove, H J Yost
Nov 2, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Bert van der ZwaagHans Van Bokhoven

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Citations

Apr 6, 2006·Pediatric Cardiology·V Demarchi Aiello, J Xavier-Neto
Jan 25, 2012·Pediatric Cardiology·R Thomas CollinsMartin G St John Sutton
Jan 19, 2007·Nature Clinical Practice. Cardiovascular Medicine·Takaaki MatsuiJuan Carlos Izpisúa Belmonte
Nov 24, 2005·Nature Reviews. Genetics·Margaret BuckinghamStéphane Zaffran
Mar 11, 2009·Nature Reviews. Genetics·Sridhar Hannenhalli, Klaus H Kaestner
May 25, 2011·Molecular and Cellular Biology·Shoumei Bai, Tom K Kerppola
Apr 26, 2007·Annual Review of Cell and Developmental Biology·Radwan Abu-Issa, Margaret L Kirby
Aug 23, 2012·PloS One·Karla R WiehagenJonathan S Maltzman
Jul 28, 2013·International Reviews of Immunology·Veerle Fleskens, Ruben van Boxtel
Jul 7, 2007·Expert Opinion on Therapeutic Targets·Henry B KoonPhilip W Tucker
Mar 28, 2007·Heart Failure Clinics·Jau-Nian ChenJohn D Mably
Apr 15, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Thomas Bartman, Jay Hove
Mar 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sneha RamakrishnaVladimir V Kalinichenko
Sep 12, 2006·Molecular and Cellular Neurosciences·Ulrich SchüllerDavid H Rowitch
Mar 22, 2008·The Annals of Thoracic Surgery·Peter J Gruber
Jul 14, 2007·Mechanisms of Development·Sophie AstrofRichard O Hynes
Apr 6, 2013·Journal of Molecular and Cellular Cardiology·Daniel M DeLaughterJoey V Barnett
May 22, 2016·Seminars in Cell & Developmental Biology·Hye Young KimLance A Davidson
Aug 26, 2016·Nature Communications·Claire AndersonClaudio D Stern
Jan 26, 2018·Journal of Cardiovascular Development and Disease·Kenzo IvanovitchMiguel Torres
Dec 15, 2016·Development·Maria L Golson, Klaus H Kaestner
Jan 6, 2015·The Journal of Comparative Neurology·Ezequiel MendozaConstance Scharff
Sep 6, 2006·Circulation·Sridhar HannenhalliThomas P Cappola
Oct 28, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·R A Moreno-RodriguezR R Markwald
Jan 31, 2020·Wiley Interdisciplinary Reviews. Developmental Biology·Marissa CoGenevieve Konopka
Jan 21, 2017·Case Reports in Medicine·Sukhdeep BhogalTimir Paul
Oct 29, 2020·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Lot Snijders BlokSimon E Fisher
Feb 10, 2021·Nature Biotechnology·Lika DrakhlisRobert Zweigerdt
Dec 12, 2020·Trends in Genetics : TIG·Laetitia HermanReiner A Veitia

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