Advanced Chemical Computing Using Discrete Turing Patterns in Arrays of Coupled Cells

Frontiers in Chemistry
František MuzikaIgor Schreiber

Abstract

We examine dynamical switching among discrete Turing patterns that enable chemical computing performed by mass-coupled reaction cells arranged as arrays with various topological configurations: three coupled cells in a cyclic array, four coupled cells in a linear array, four coupled cells in a cyclic array, and four coupled cells in a branched array. Each cell is operating as a continuous stirred tank reactor, within which the glycolytic reaction takes place, represented by a skeleton inhibitor-activator model where ADP plays the role of activator and ATP is the inhibitor. The mass coupling between cells is assumed to be operating in three possible transport regimes: (i) equal transport coefficients of the inhibitor and activator (ii) slightly faster transport of the activator, and (iii) strongly faster transport of the inhibitor. Each cellular array is characterized by two pairs of tunable parameters, the rate coefficients of the autocatalytic and inhibitory steps, and the transport coefficients of the coupling. Using stability and bifurcation analysis we identified conditions for occurrence of discrete Turing patterns associated with non-uniform stationary states. We found stable symmetric and/or asymmetric discrete Turing pa...Continue Reading

References

Oct 1, 1969·Journal of Theoretical Biology·L Wolpert
Aug 1, 1984·Biophysical Chemistry·F Morán, A Goldbeter
Jun 6, 1998·Journal of Theoretical Biology·M Kerszberg, L Wolpert
Jul 24, 1998·Biophysical Journal·V L Tlapak-Simmons, G D Reinhart
Feb 1, 1993·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·M YoshimotoY Mori
Jun 11, 1990·Physical Review Letters·V Castets De Kepper P
Aug 5, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·H Meinhardt, A Gierer
Jun 21, 2001·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·A Sanz-AnchelerguesA P Muñuzuri
Dec 12, 2001·Physical Review Letters·M DolnikI R Epstein
Dec 18, 2001·Biophysical Chemistry·F HynneP G Sørensen
May 1, 1965·Journal of Molecular Biology·J MONODJ P CHANGEUX
Jul 21, 2004·Progress in Biophysics and Molecular Biology·Herbert M Sauro, Boris N Kholodenko
Sep 29, 2005·Physical Chemistry Chemical Physics : PCCP·J Gorecka, J Gorecki
Oct 26, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·J Gorecka, J Gorecki
Mar 4, 2006·The Journal of Chemical Physics·J Gorecka, J Gorecki
Jan 19, 2007·Biochimica Et Biophysica Acta·Dominica MediavillaIsabel V Baanante
Feb 3, 2007·The Journal of Physical Chemistry. a·Joanna N GoreckaYasuhiro Igarashi
Apr 16, 1993·Science·A HjelmfeltJ Ross
Jun 21, 2008·Journal of Biomedicine & Biotechnology·Jaw-Chyng Lue, Wai-Chi Fang
Nov 18, 2008·Current Biology : CB·Lukasz KozubowskiDaniel J Lew
May 9, 2009·Science·Judit HorváthPatrick De Kepper
Nov 13, 2009·The Journal of Physical Chemistry. B·Marcos PitaEvgeny Katz
May 11, 2010·Brain Research Reviews·Claudia Verderio, Michela Matteoli
Feb 2, 2011·Molecular Systems Biology·Jongmin Kim, Erik Winfree
Mar 23, 2011·The Journal of Physical Chemistry. B·Kouichi AsakuraMasazumi Kamata
Jul 22, 2011·Nature·Lulu QianJehoshua Bruck
Jul 26, 2011·Computer Methods and Programs in Biomedicine·Diego Alexander Garzón-AlvaradoDorian Luis Linero Segrera
Dec 21, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Julian HolleyAndrew Adamatzky
Feb 7, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Andrew AdamatzkyDaniel Younger
Dec 20, 2012·Scientific Reports·Amarendra BaduguDagmar Iber
Apr 26, 2013·Evolutionary Computation·Gerard HowardAndrew Adamatzky
Jun 5, 2013·The Journal of Physical Chemistry. B·Vladimir PrivmanEvgeny Katz
Nov 5, 2013·The Journal of Chemical Physics·František Muzika, Igor Schreiber
Mar 1, 2014·Human Reproduction·T H HerengB S Skålhegg
May 16, 2014·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·J GoreckiAndrew Adamatzky
Feb 3, 2015·The Journal of Physiology·Elisabeth Engl, David Attwell
Oct 2, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Najib J MajajJames J DiCarlo
Jan 11, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Evgeny Katz, Brian E Fratto
Apr 3, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Brian E FrattoEvgeny Katz
Nov 2, 2016·Molecular Biology of the Cell·Chris Snowdon, Mark Johnston

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