Advanced chronic kidney disease: a strong risk factor for Clostridium difficile infection

The Korean Journal of Internal Medicine
Sun Chul KimHyoung-Kyu Kim

Abstract

It has been suggested that chronic kidney disease (CKD) is a risk factor for Clostridium difficile infection (CDI) and is associated with increased mortality among patients infected with C. difficile. However, recent studies of the clinical impact of CKD on CDI in Asians are still insufficient. We sought to determine the relationship between CKD and CDI in a Korean population. This was a single-center, retrospective case-control study. In total, 171 patients with CDI were included as cases and 342 age- and gender-matched patients without CDI were used as controls. We compared the prevalence of CKD in the study sample and identified independent risk factors that could predict the development or prognosis of CDI. Independent risk factors for CDI included stage IV to V CKD not requiring dialysis (odds ratio [OR], 2.90) and end-stage renal disease requiring dialysis (OR, 3.34). Patients with more advanced CKD (estimated glomerular filtration rate < 30) and CDI showed higher in-hospital mortality and poorer responses to the initial metronidazole therapy. More advanced CKD is an independent risk factor for CDI and is associated with higher in-hospital mortality and poor treatment responses in CDI patients. Thus, in CKD patients, care...Continue Reading

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Citations

Dec 18, 2016·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Laura Paláu-DávilaAdrián Camacho-Ortiz
Oct 13, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Megan M SeddonMajdi N Al-Hasan
Aug 16, 2016·Infectious Diseases and Therapy·Alberto Cózar-LlistóJavier Cobo
Sep 3, 2020·The Korean Journal of Internal Medicine·So Mi Kim, Il Han Song
Nov 20, 2020·Open Forum Infectious Diseases·Travis J CarlsonKevin W Garey
Jan 13, 2021·Journal of Clinical Medicine·Sylwia DudziczMarcin Adamczak
Mar 27, 2021·Diseases of the Colon and Rectum·Vitaliy PoylinUNKNOWN Prepared by the Clinical Practice Guidelines Committee of The American Society of Colon and Rectal Surgeons

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