Advanced colon cancer: antiprogressive immunotherapy using an autologous hemoderivative.

Medical Oncology
Eduardo Lasalvia-PriscoJoshemaria Larrañga

Abstract

Advanced colon cancer patients, acquired-chemotherapy resistant and in progression, are therapeutically terminal. We tested a recently described medical procedure using a thermostable autologous hemoderivative purported to inhibit tumor growth possibly through an immunological mechanism of action. Metastatic colon cancer patients chemotherapy-resistant, high CEA plasma levels, in progression, were 2-group randomized. Group 1 received the test procedure and Group 2 adequate control measures. During an 8-mo follow-up period (n = 101), tumor growth, number of cases attaining clinical nonprogressive status, and mortality were assessed monthly. Immunological effect was assessed by delayed-type hypersensitivity test and lymphocyte proliferation assay. Responding-tumors histopathologies were studied. In a significant number of cases, the test procedure promoted inhibition of tumor growth, nonprogressive disease status, and lower cumulative mortality. These clinical results were associated with polyvalent immunization against several tested antigens: the hemoderivative used for treatment, the blood tumor markers, and the regulatory lymphocyte population (CD4+CD25+). Interference with this regulatory activity could explain the selective...Continue Reading

Citations

Jul 5, 2006·Breast Cancer Research and Treatment·Eduardo Lasalvia-PriscoJoshemaria Larrañaga
Mar 3, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C F M EvansD Kumar
Aug 27, 2009·Biologics : Targets & Therapy·Eduardo Lasalvia-PriscoGonzalo Spera

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