Advanced correlation grid: Analysis and visualisation of functional connectivity among multiple spike trains

Journal of Neuroscience Methods
Mohammad Shahed MasudLiz Stuart

Abstract

This study analyses multiple spike trains (MST) data, defines its functional connectivity and subsequently visualises an accurate diagram of connections. This is a challenging problem. For example, it is difficult to distinguish the common input and the direct functional connection of two spike trains. The new method presented in this paper is based on the traditional pairwise cross-correlation function (CCF) and a new combination of statistical techniques. First, the CCF is used to create the Advanced Correlation Grid (ACG) correlation where both the significant peak of the CCF and the corresponding time delay are used for detailed analysis of connectivity. Second, these two features of functional connectivity are used to classify connections. Finally, the visualization technique is used to represent the topology of functional connections. Examples are presented in the paper to demonstrate the new Advanced Correlation Grid method and to show how it enables discrimination between (i) influence from one spike train to another through an intermediate spike train and (ii) influence from one common spike train to another pair of analysed spike trains. The ACG method enables scientists to automatically distinguish between direct con...Continue Reading

References

Jan 1, 1991·Experimental Brain Research·P M GochinG L Gerstein
May 1, 1989·Journal of Neurophysiology·A M AertsenG Palm
Jul 29, 1994·Science·M A Wilson, B L McNaughton
May 1, 1995·Neural Computation·P KönigW Singer
Dec 24, 1997·Journal of Neuroscience Methods·R DahlhausJ Sandkühler
Jul 13, 1999·Journal of Neurophysiology·Z LiB G Lindsey
Nov 8, 2003·Biological cybernetics·Michael EichlerJürgen Sandkühler
Apr 29, 2004·Nature Neuroscience·Emery N BrownPartha P Mitra
Oct 29, 2004·PLoS Biology·Olaf Sporns, Rolf Kötter
Aug 16, 2006·Neural Computation·Gaby SchneiderDanko Nikolić
Sep 26, 2006·Journal of Computational Neuroscience·Danko Nikolić
Dec 7, 2007·Journal of Neuroscience Methods·Il ParkJosé C Príncipe
Dec 17, 2008·Current Opinion in Neurobiology·Ian H StevensonKonrad P Körding
Jan 13, 2009·Journal of Computational Neuroscience·Aatira G NedungadiMingzhou Ding
Jul 2, 2009·Journal of Computational Neuroscience·Birgit KrienerStefan Rotter
Jan 18, 2011·Journal of Neuroscience Methods·Mohammad Shahed Masud, Roman Borisyuk
Feb 14, 2012·The European Journal of Neuroscience·Danko NikolićWolf Singer
Apr 24, 2013·Neural Computation·Robert HaslingerEmery Brown
Jun 9, 2016·PLoS Computational Biology·Stojan Jovanović, Stefan Rotter

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