Advanced diffusion imaging for assessing normal white matter development in neonates and characterizing aberrant development in congenital heart disease

NeuroImage. Clinical
S KarmacharyaP E Grant

Abstract

Elucidating developmental trajectories of white matter (WM) microstructure is critically important for understanding normal development and regional vulnerabilities in several brain disorders. Diffusion Weighted Imaging (DWI) is currently the method of choice for in-vivo white matter assessment. A majority of neonatal studies use the standard Diffusion Tensor Imaging (DTI) model although more advanced models such as the Neurite Orientation Dispersion and Density Imaging (NODDI) model and the Gaussian Mixture Model (GMM) have been used in adult population. In this study, we compare the ability of these three diffusion models to detect regional white matter maturation in typically developing control (TDC) neonates and regional abnormalities in neonates with congenital heart disease (CHD). Multiple b-value diffusion Magnetic Resonance Imaging (dMRI) data were acquired from TDC neonates (N = 16) at 38 to 47 gestational weeks (GW) and CHD neonates (N = 19) aged 37 weeks to 41 weeks. Measures calculated from the diffusion signal included not only Mean Diffusivity (MD) and Fractional Anisotropy (FA) derived from the standard DTI model, but also three advanced diffusion measures, namely, the fiber Orientation Dispersion Index (ODI), th...Continue Reading

Citations

May 24, 2019·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Giulia SommarivaPaola Cogo
Sep 5, 2019·Current Opinion in Pediatrics·Brian R WhiteMatthew P Kirschen
Nov 7, 2019·Current Opinion in Pediatrics·Brian R WhiteMatthew P Kirschen
Aug 20, 2020·Journal of Neuroscience Methods·Kouhei KamiyaShigeki Aoki
Jul 30, 2021·Frontiers in Neuroscience·Anni CopelandJetro J Tuulari

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Methods Mentioned

BETA
Density Imaging

Software Mentioned

Advanced Normalization Tools ( ANTs )
R
NODDI
Slicer
FSL FLIRT
MATLAB

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