Advanced Drug-Eluting Poly (Vinyl Chloride) Surfaces Deposited by Spin Coating

Medicina
Oana Cristina DutaEcaterina Andronescu

Abstract

Background and objectives: Medical devices such as catheters are used on a large scale to treat heart and cardiovascular diseases. Unfortunately, they present some important drawbacks (structure failure, calcifications, infections, thrombosis, etc.), with the main side effects occurring due to adhesion and proliferation of bacteria and living cells on the surface of the implanted devices. The aim of this work is to modify the surface of polyvinyl chloride (PVC), an affordable biocompatible material, in order to reduce these aforementioned side effects. Materials and Methods: The surface of PVC was modified by depositing a thin layer also of PVC that incorporates an active substance, dicoumarol (a well-known anticoagulant), by spin coating process. The modified surfaces were analyzed by Fourier-transform infrared (FT-IR) microscopy, Fourier-transform infrared (FT-IR) spectroscopy, Ultraviolet-visible spectroscopy (UV-VIS), and Scanning electron microscopy (SEM) in order to determine the surface morphology and behavior. The samples were tested for Gram-positive (S. aureus ATCC 25923) and Gram-negative (P. aeruginosa ATCC 27853) standard strains from American Type Culture Collection (ATCC). Results: The material obtained had a smo...Continue Reading

References

Jul 1, 1971·Biochemical Pharmacology·S Garten, W D Wosilait
Jul 1, 1995·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·S Nagaoka, H Kawakami
May 23, 2002·Journal of Biomaterials Science. Polymer Edition·Ayşe Gönen Karakeçili, Menemşe Gümüşderelioglu
May 8, 2003·Journal of Biomedical Materials Research. Part a·Ayako OyaneTakashi Nakamura
Mar 31, 2004·Bioorganic & Medicinal Chemistry·Khalid Mohammed KhanShahnaz Perveen
Aug 5, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ren-Jei ChungTsung-Shune Chin
Mar 2, 2010·Colloids and Surfaces. B, Biointerfaces·Ahmad AsadinezhadIvan Chodák
Mar 20, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Benjamin O PattersonPeter J E Holt
Sep 20, 2011·Journal of Medicinal Chemistry·Maria J MatosDolores Viña
Jun 14, 2012·International Journal of Biomaterials·Achala de MelAlexander M Seifalian
Sep 4, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Katherine R ZodrowMenachem Elimelech
Oct 31, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Amanda Y WangMeg J Jardine
Oct 13, 2014·Nature Biotechnology·Daniel C LeslieDonald E Ingber
May 24, 2015·Journal of Dental Research·F SongD Ren
Jan 23, 2016·Chemical Reviews·Guanying ChenParas N Prasad
Feb 6, 2017·ACS Applied Materials & Interfaces·Elaheh A ChamsazAbraham Joy
Nov 29, 2017·Nanotechnology, Science and Applications·Marianne GunellErkki Eerola
Nov 9, 2018·World Journal of Microbiology & Biotechnology·Tapas DasUtpal Ch De

❮ Previous
Next ❯

Methods Mentioned

BETA
The Energy Dispersive Spectroscopy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Monica Luminita BadeaDaniela Predoi
International Journal of Nanomedicine
Alejandra Arévalo-GallegosRoberto Parra-Saldívar
Journal of Biomedical Materials Research. Part a
Alexander JonesHitesh Handa
© 2021 Meta ULC. All rights reserved