Advanced electrocardiographic predictors of mortality in familial dysautonomia

Autonomic Neuroscience : Basic & Clinical
I SolaimanzadehM J Hilz

Abstract

To identify electrocardiographic predictors of mortality in patients with familial dysautonomia (FD). Ten-minute resting high-fidelity 12-lead electrocardiograms (ECGs) were obtained from 14 FD patients and 14 age/gender-matched healthy subjects. Multiple conventional and advanced ECG parameters were studied for their ability to predict mortality over a subsequent 4.5-year period, including representative parameters of heart rate variability (HRV), QT variability (QTV), T-wave complexity, signal averaged ECG, and 3-dimensional ECG. Four of the 14 FD patients died during the follow-up period, three with concomitant pulmonary disorder. Of the ECG parameters studied, increased non-HRV-correlated QTV and decreased HRV were the most predictive of death. Compared to controls as a group, FD patients also had significantly increased ECG voltages, JTc intervals and waveform complexity, suggestive of structural heart disease. Increased QTV and decreased HRV are markers for increased risk of death in FD patients. When present, both markers may reflect concurrent pathological processes, especially hypoxia due to pulmonary disorders and sleep apnea.

References

Oct 1, 1977·American Heart Journal·R ReshefJ Manelis
Jun 1, 1992·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·V K SomersF M Abboud
Sep 24, 1987·The New England Journal of Medicine·J M McLenachanH J Dargie
Sep 1, 1984·Respiration Physiology·D E MillhornT G Waldrop
Mar 1, 1983·Journal of the Autonomic Nervous System·K KoizumiM Kollai
Jul 1, 1983·Journal of the Neurological Sciences·N GadothP Lavie
Feb 15, 1993·Annals of Internal Medicine·S ViskinS Laniado
Dec 31, 1997·Circulation·D L Eckberg
Oct 24, 1998·Journal of Cardiovascular Electrophysiology·W L AtigaR D Berger
Dec 9, 1998·Journal of Sleep Research·R FerriS Pettinato
May 4, 1999·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·J S GlicksteinD Friedman
Sep 2, 2000·Journal of Cardiovascular Electrophysiology·M MalikA J Camm
Feb 27, 2001·Journal of Human Hypertension·P DilaverisJ Gialafos
Dec 26, 2001·American Journal of Respiratory and Critical Care Medicine·R S Leung, T D Bradley
Mar 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ary L GoldbergerH Eugene Stanley
Jul 26, 2002·Journal of Cardiovascular Electrophysiology·Juha S PerkiömäkiArthur J Moss
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Luciano BernardiFelicia B Axelrod
Mar 5, 2003·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Timothy J MaderGeoffrey Scriver
Feb 26, 2004·Muscle & Nerve·Felicia B Axelrod
Jul 21, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A E PontiroliG Fragasso
Aug 3, 2004·Journal of Electrocardiology·Elin TrägårdhJonas Pettersson
Oct 7, 2004·Journal of the American College of Cardiology·Mark C HaigneyMulticenter Automatic Defibrillator Implantation Trial II investigators
Oct 16, 2004·Journal of Electrocardiology·Niles J BatdorfTodd T Schlegel
Mar 16, 2005·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Gabrielle Gold-von SimsonFelicia B Axelrod
Jan 3, 2006·Journal of Electrocardiology·M Atiar RahmanTodd T Schlegel
Mar 15, 2006·Journal of Electrocardiology·Bjorn H BatdorfTodd T Schlegel
Jun 17, 2006·Current Problems in Pediatric and Adolescent Health Care·Gabrielle Gold-von Simson, Felicia B Axelrod
Aug 22, 2006·Journal of Electrocardiology·Vito Starc, Todd T Schlegel

Citations

Nov 17, 2009·Pediatric Cardiology·Udi NussinovitchNaomi Nussinovitch
Nov 10, 2015·International Journal of Cardiology·Josef FinstererConcha Maeztu
Dec 16, 2011·Pediatric Pulmonology·Michael S CarrollDebra E Weese-Mayer
Jan 30, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Mathias BaumertPaul G A Volders
Oct 7, 2017·Pacing and Clinical Electrophysiology : PACE·Nataliia BotsvaDmitriy Chernetchenko
Jan 11, 2019·Bulletin of Experimental Biology and Medicine·S S NikitinS V Revenko
Jul 22, 2018·Brain and Behavior·Ksenija CankarVito Starc

Related Concepts

Anoxemia
Cardiac Arrhythmia
Dysautonomia, Familial
Electrocardiographic Recorders
Pulse Rate
Left Ventricular Structure
Decline, Mortality
Respiratory Failure
Viral Markers
Sudden Cardiac Arrest

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