Advanced Functional Tumor Imaging and Precision Nuclear Medicine Enabled by Digital PET Technologies

Contrast Media & Molecular Imaging
Chadwick L WrightMichael V Knopp

Abstract

The purpose of this article is to provide a brief overview of the background, basic principles, technological evolution, clinical capabilities, and future directions for functional tumor imaging as PET evolves from the conventional photomultiplier tube-based platform into a fully digital detector acquisition platform. The recent introduction of solid-state digital photon counting PET detector is the latest evolution of clinical PET which enables faster time-of-flight timing resolution that leads to more precise localization of the annihilation events and further contributes to reduction in partial volume and thus makes high definition and ultrahigh definition PET imaging feasible with current standard acquisition procedures. The technological advances of digital PET can be further leveraged by optimizing many of the acquisition and reconstruction methodologies to achieve faster image acquisition to improve cancer patient throughput, lower patient dose in accordance with ALARA, and improved quantitative accuracy to enable biomarker capability. Digital PET technology will advance molecular imaging capabilities beyond oncology and enable Precision Nuclear Medicine.

References

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Nov 20, 2016·PET Clinics·Chadwick L WrightMichael V Knopp

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Citations

Jan 1, 2018·Current Pharmaceutical Design·Luigi Landini
Oct 1, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Antoine Verger, Eric Guedj
May 5, 2020·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Shuchun YuMing Pang
Jan 9, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Francisco Fuentes-OcampoIgnasi Carrió
Apr 27, 2020·EJNMMI Physics·Julien SalvadoriDavid Sarrut
Jan 12, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Diego Alfonso López-MoraIgnasi Carrió
Dec 12, 2020·Nuclear Medicine Communications·Francisco Fuentes-OcampoIgnasi Carrió
Mar 12, 2021·Frontiers in Medicine·Olivier DelcroixSolène Querellou
Mar 22, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Claudia OrtegaUr Metser
Aug 17, 2021·Radiologic Clinics of North America·Chadwick L WrightMichael V Knopp
Oct 6, 2021·Expert Review of Medical Devices·Luca Filippi, Orazio Schillaci

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Software Mentioned

dPET

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