PMID: 15220206Jun 29, 2004Paper

Advanced glycation end product interventions reduce diabetes-accelerated atherosclerosis

Diabetes
Josephine M ForbesTerri J Allen

Abstract

Advanced glycation end product (AGE) formation may contribute to the progression of atherosclerosis, particularly in diabetes. The present study explored atherosclerosis in streptozotocin-induced diabetic apolipoprotein E-deficient (apoE-/-) mice that were randomized (n = 20) to receive for 20 weeks no treatment, the AGE cross-link breaker ALT-711, or the inhibitor of AGE formation aminoguanidine (AG). A sixfold increase in plaque area with diabetes was attenuated by 30% with ALT-711 and by 40% in AG-treated mice. Regional distribution of plaque demonstrated no reduction in plaque area or complexity within the aortic arch with treatment, in contrast to the thoracic and abdominal aortas, where significant attenuation was seen. Diabetes-associated accumulation of AGEs in aortas and plasma and decreases in skin collagen solubility were ameliorated by both treatments, in addition to reductions in the vascular receptor for AGE. Collagen-associated reductions in the AGEs carboxymethyllysine and carboxyethyllysine were identified with both treatments. Diabetes was also accompanied by aortic accumulation of total collagen, specifically collagens I, III, and IV, as well as increases in the profibrotic cytokines transforming growth facto...Continue Reading

References

Nov 1, 1967·Clinica Chimica Acta; International Journal of Clinical Chemistry·H Stegemann, K Stalder
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Jun 1, 1993·The Journal of Clinical Investigation·D G DyerJ W Baynes
Jan 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S HoriuchiK Takahashi
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·B H WolffenbuttelB I Lévy
Feb 19, 2002·Kidney International·Thorsten P DegenhardtJohn W Baynes
May 29, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Cyriel J A L MentinkBruce H R Wolffenbuttel
Nov 27, 2002·Circulation·Loredana G BucciarelliAnn Marie Schmidt
Mar 21, 2003·Archives of Biochemistry and Biophysics·Shengzu YangJohn W Baynes
Jun 6, 2003·The New England Journal of Medicine·David M NathanUNKNOWN Epidemiology of Diabetes Interventions and Complications Research Group
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Josephine M ForbesMark E Cooper
Oct 22, 2003·Archives of Biochemistry and Biophysics·Sara VasanHank Founds
Mar 17, 2004·Circulation·Riccardo CandidoKarin A Jandeleit-Dahm

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Citations

May 15, 2010·Herz·Alin Stirban
May 12, 2012·Der Pathologe·J Kunz
Jul 14, 2006·Pediatric Surgery International·Min ChenCarroll M Harmon
Nov 8, 2006·Current Hypertension Reports·Georgia Soldatos, Mark Emmanuel Cooper
Sep 18, 2007·Cell Biochemistry and Biophysics·Sudesh VasdevPawan Singal
Mar 23, 2005·Current Opinion in Pharmacology·Burton E Sobel, David J Schneider
Jun 6, 2009·Antioxidants & Redox Signaling·Anne Negre-SalvayreManuel Portero-Otín
Apr 28, 2010·Journal of Cardiovascular Pharmacology·Wing Tak WongYu Huang
Aug 24, 2007·Clinical and Experimental Pharmacology & Physiology·G H Tesch
Feb 23, 2008·Clinical and Experimental Pharmacology & Physiology·Karin Jandeleit-DahmAino Soro-Paavonen
Jun 1, 2010·Journal of Diabetes Investigation·Munehiro KitadaGeorge L King
Mar 28, 2012·Journal of Diabetes Investigation·Yasuhiko Yamamoto, Hiroshi Yamamoto
Jun 10, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Xue GaoCuihua Zhang
Feb 22, 2008·PPAR Research·Anna C Calkin, Merlin C Thomas
Apr 11, 2012·International Journal of Vascular Medicine·Steven Daniel FunkA Wayne Orr
Nov 24, 2011·Experimental Diabetes Research·Myat Thu Thu WinHiroshi Yamamoto
Mar 20, 2012·Chemistry Central Journal·Simon Asbjørn LarsenSuresh Is Rattan
Jan 23, 2009·Journal of the American Society of Nephrology : JASN·Melinda T CoughlanJosephine M Forbes
Feb 24, 2006·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Anna C Calkin, Terri J Allen
Feb 14, 2013·Heart Failure Reviews·Vijaya Lakshmi BodigaSreedhar Bodiga
May 3, 2014·Journal of Fluorescence·Sheraz Ahmad BhatBilqees Bano
Apr 2, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Stephen P Gray, Karin Jandeleit-Dahm
Oct 11, 2012·Bioscience, Biotechnology, and Biochemistry·Ryu-ichiro NagamatsuMakoto Ubukata
Jun 16, 2007·Journal of Inherited Metabolic Disease·N C den HollanderA J Smit
Dec 21, 2013·Clinical and Experimental Nephrology·Takashige KuwabaraKazuwa Nakao

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