Advanced glycation end products and their receptors did not show any association with body mass parameters in metabolically healthy adolescents

Acta Paediatrica
Ma Eugenia Garay-SevillaJaime Uribarri

Abstract

We determined the relationship between circulating advanced glycation end products (AGEs), AGE receptors and homeostatic model assessment for insulin resistance (HOMA-IR) in metabolically healthy obese and normal weight adolescents. In 2015, we recruited 80 normal weight adolescents and 80 with obesity from schools Leon city, Mexico, and put them into metabolically healthy (HOMA-IR <3.0) and unhealthy (HOMA-IR >3.0) groups. We measured their body mass index (BMI) and carried out detailed blood analyses. We found a higher triglycerides, triglycerides/high-density lipoproteins cholesterol (TG/HDL-C) index, HOMA-IR, tumour necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in the metabolically healthy group and found correlations between HOMA-IR with BMI, the TG/HDL-C index and IL-6 and the TG/HDL-C index and BMI and (TNF-α). There was no correlation between markers of obesity and circulating N-carboxymethyl-lysine (CML) or soluble receptor for advanced glycation end products (sRAGE). Some unhealthy adolescents had higher CML (15.5 ± 2.7 U/mL, p < 0.028) and sRAGE (3123 ± 1364 pg/mL, p < 0.001) than the healthy group. HOMA-IR and the TG/HDL-C index were associated with BMI and inflammation markers. CML and sRAGE were not assoc...Continue Reading

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Citations

Aug 15, 2019·Hormone Research in Pædiatrics·Reyna Rodríguez-MorteraMa Eugenia Garay-Sevilla

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