PMID: 8949973Oct 1, 1996Paper

Advanced glycation end-products and atherosclerosis

Annals of Medicine
H Vlassara

Abstract

The late rearrangements of the covalent nonenzymatic modification of proteins by glucose, called advanced glycation end-products (AGEs), have been shown to accumulate in diabetic and ageing tissues. AGEs elicit a wide range of cell-mediated responses leading to vascular dysfunction, matrix expansion and athero- and glomerulosclerosis. Cellular responses are thought to be largely induced through an AGE-specific cell-surface receptor complex (AGEr). Interaction of AGE-modified proteins with these cells may serve diverse purposes, including disposal of senescent AGE-modified molecules and initiation of tissue repair and protein turnover. In humans, the normal renal clearance rate for the AGE-degradation products found in serum, AGE peptides (AGEp), correlates inversely with renal creatinine clearance rate. Of note, circulating AGEp include reactive intermediates which readily attach covalently to either insoluble matrix collagen or serum proteins, e.g. low-density lipoproteins (LDL), to form AGEp collagen and AGEp-LDL. Consistent with this, diabetic and nondiabetic patients with renal failure (a group highly susceptible to accelerated atherosclerosis) exhibit markedly elevated AGE-modified serum LDL. In summary, in addition to glu...Continue Reading

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H VlassaraR Bucala
Jan 1, 1992·Diabetologia·D Edelstein, M Brownlee
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·H P HammesM Brownlee
Feb 1, 1991·Zeitschrift für Ernährungswissenschaft·D G DyerJ W Baynes
Sep 19, 1991·The New England Journal of Medicine·Z MakitaH Vlassara
Oct 1, 1991·Metabolism: Clinical and Experimental·E N Ellis, B H Good
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M KiharaP A Low
Jul 31, 1989·Biochemical and Biophysical Research Communications·H NakayamaS Nakagawa
Apr 20, 1989·The New England Journal of Medicine·I Saenz de TejadaR A Cohen
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H VlassaraA Cerami
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·C W YangL J Striker
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·R BucalaH Vlassara
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·H VlassaraM Steffes
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R BucalaH Vlassara
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y M LiH Vlassara

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Citations

May 15, 2010·Herz·Alin Stirban
Nov 13, 2013·European Biophysics Journal : EBJ·Mohd Shahnawaz KhanJaved Musarrat
Apr 5, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Tsutomu YasukawaYuichiro Ogura
Mar 31, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Megumi HirataYuichiro Ogura
May 12, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·F AntoliniR M Fagugli
Sep 29, 2001·The American Journal of Cardiology·H E Lebovitz
Aug 26, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·S FrankeG Stein
Sep 25, 2002·Life Sciences·Yosuke InagakiZenji Makita
Jan 12, 1999·Mechanisms of Ageing and Development·A J BaileyL Knott
May 28, 2003·International Journal of Cardiology·Jaffar Ali Raza, Assad Movahed
Dec 10, 1999·Diabetes Research and Clinical Practice·S E Bursell, G L King
May 19, 2000·Experimental Gerontology·P D ReavenJ L Witztumc
Oct 12, 2000·Free Radical Biology & Medicine·G T WondrakM K Jacobson
Nov 7, 2008·The British Journal of Nutrition·Megha SaraswatG Bhanuprakash Reddy
Aug 26, 2011·The British Journal of Nutrition·P MuthennaG Bhanuprakash Reddy
Sep 28, 2005·Nature Clinical Practice. Cardiovascular Medicine·Robert A O'Rourke
Jun 9, 2001·Antioxidants & Redox Signaling·E Bourdon, D Blache
Jul 2, 2004·ILAR Journal·Larissa EiseleinJohn C Rutledge
Apr 9, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jeannete PuñalAlberto Ruano-Ravina
Feb 2, 2000·Current Opinion in Nephrology and Hypertension·M G Jakoby, C F Semenkovich
Aug 17, 1999·Annual Review of Nutrition·I Tabas
Oct 29, 2002·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Hiroyuki UkedaMasayoshi Sawamura
Mar 24, 2005·Treatments in Endocrinology·Sabita S Soedamah-Muthu, Coen D A Stehouwer
Jun 1, 2014·The Proceedings of the Nutrition Society·Antonis VlassopoulosEmilie Combet
Oct 15, 2014·Diabetes & Metabolic Syndrome·Alok Raghav, Jamal Ahmad
Feb 22, 2000·Clinical Cornerstone·J C LaRosa
Nov 18, 2010·Immunological Investigations·Zohara SternbergFrederick Munschauer
Jan 5, 2002·Expert Opinion on Investigational Drugs·S VasanH W Founds
Oct 10, 2009·Pharmacological Reports : PR·Sandip Patel, Dev Santani
Mar 7, 2012·The Medical Clinics of North America·Dilbahar S MoharJagat Narula
Jan 17, 2012·Free Radical Biology & Medicine·Stefanie GrimmTilman Grune
Sep 17, 2008·Journal of Endodontics·Mariana Ferreira LeiteJosé Nicolau
Dec 22, 2007·Journal of Biochemical and Biophysical Methods·Shamila FatimaM Saleemuddin
Sep 15, 2015·Biochimie·Amit Kumar DindaSwagata Dasgupta
Aug 30, 2008·The Mount Sinai Journal of Medicine, New York·Alin StirbanDiethelm Tschoepe

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