Advanced glycation end products enhance monocyte activation during human mixed lymphocyte reaction

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Katsuhisa OhashiNoriaki Tanaka

Abstract

Posttransplant diabetes mellitus (PTDM) is a frequent complication among transplant recipients. Ligation of advanced glycation end products (AGEs) with their receptor (RAGE) on monocytes/macrophages plays roles in the diabetes complications. The enhancement of adhesion molecule expression on monocytes/macrophages activates T-cells, leading to reduced allograft survival. We investigated the effect of four distinct AGE subtypes (AGE-2/AGE-3/AGE-4/AGE-5) on the expressions of intracellular adhesion molecule (ICAM)-1, B7.1, B7.2 and CD40 on monocytes, the production of interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha and the proliferation of T-cells during human mixed lymphocyte reaction (MLR). AGE-2 and AGE-3 selectively induced the adhesion molecule expression, cytokine production and T-cell proliferation. The AGE-induced up-regulation of adhesion molecule expression was involved in the cytokine production and T-cell proliferation. AGE-2 and AGE-3 up-regulated the expression of RAGE on monocytes; therefore, the AGEs may activate monocytes, leading to the up-regulation of adhesion molecule expression, cytokine production and T-cell proliferation.

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Citations

Mar 13, 2014·Progress in Lipid Research·Nishika Sahini, Jürgen Borlak
Oct 4, 2014·Virology·Sven Moller-Tank, Wendy Maury
Jul 28, 2015·Mechanisms of Ageing and Development·Dorit BennmannRüdiger Horstkorte
Mar 14, 2014·Redox Biology·Christiane OttAndreas Simm
Nov 2, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Daniel PrantnerStefanie N Vogel
Jul 25, 2021·International Journal of Environmental Research and Public Health·Juan SalazarValmore Bermúdez

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