Advanced glycation end products in idiopathic frozen shoulders

Journal of Shoulder and Elbow Surgery
Kyu Rim HwangJudie R Walton

Abstract

The pathophysiologic mechanisms behind proliferation of fibroblasts and deposition of dense collagen matrix in idiopathic frozen shoulder remain unclear. Accumulation of advanced glycation end products (AGEs) with cross-linking and stabilization of collagen has been hypothesized to contribute to this pathophysiologic process. This study investigated whether the immunoreactivity of AGEs is higher in patients with idiopathic frozen shoulder than in the control groups. Shoulder capsule samples were collected from 8 patients with idiopathic frozen shoulder, 6 with unstable shoulders (control 1), and 8 with rotator cuff tears (control 2). The samples were hematoxylin and eosin stained and analyzed by immunohistochemistry using antibodies against AGEs. Immunoreactivities were rated in a blinded fashion from none (0) to strong (3). Immunohistochemical distribution within the capsule was noted. Frozen shoulder patients had greater frequency and severity of self-reported pain (P = .02) than rotator cuff tear patients and more restricted range of motion in all planes (P < .05) than patients of the instability and rotator cuff tear groups. Hematoxylin and eosin-stained capsular tissue from frozen shoulder showed fibroblastic proliferation...Continue Reading

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Citations

Dec 1, 2017·The American Journal of Sports Medicine·Jonathon Z B CherNeal L Millar
Apr 24, 2019·PloS One·Moeed AkbarNeal L Millar
Sep 26, 2017·Molecular Medicine Reports·Jiaming CuiDaping Wang
Nov 23, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jinfu ChenWeimin Zhu
Nov 19, 2020·Journal of Experimental Orthopaedics·T KraalR C T Koorevaar
Jan 30, 2021·JBJS Reviews·Christopher M JumpCharalambos P Charalambous
Apr 14, 2020·Journal of Shoulder and Elbow Surgery·Toshihisa YanoEiji Itoi
Jul 28, 2020·Journal of Shoulder and Elbow Surgery·Hyung Bin ParkJaehoon Jung
May 29, 2021·Frontiers in Medicine·Daniel de la SernaLeo Pruimboom
Aug 24, 2021·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Alexander J EckertReinhardW Holl
Sep 7, 2021·Rheumatology International·Michel Gcam MertensFilip Struyf
Sep 29, 2021·BMC Musculoskeletal Disorders·Sara M SarasuaStephan G Pill

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