Advanced glycation end products influence oral cancer cell survival via Bcl-xl and Nrf-2 regulation in vitro

Oncology Letters
Shun-Yao KoShu-Shing Chang

Abstract

An irreversible non-enzymatic reaction between carbohydrates and proteins results in the formation of advanced glycation end products (AGEs). AGEs have been demonstrated to be a risk factor of complications in patients with diabetes mellitus (DM). Previous studies have suggested that patients with DM exhibit a higher rate of metastasis of oral cancer and a lower cancer-associated survival rate. The receptor for AGEs (RAGE) has been associated with angiogenesis and an increase in cancer malignancy. Previous studies have suggested that AGE-RAGE regulates cell migration via extracellular signal-regulated kinase (ERK) phosphorylation. Nuclear factor-erythroid 2-related factor 2 (Nrf-2) is associated with the regulation of tumor protein p53 (p53) and the apoptotic response of oral cancer cells. AGEs are associated with oral cancer; however, the mechanism underlying this association remains to be elucidated. The present study hypothesized that AGEs regulate Nrf-2 and downstream pathways through ERK phosphorylation. The results of the current study demonstrated that AGEs inhibit the expression of Nrf-2, p53 and Bcl-2 associated × apoptosis regulator, and increase the expression of apoptosis regulator Bcl-x protein. The effect of AGEs ...Continue Reading

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Citations

Jun 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paula SilvaGiovanni de Gaetano
May 24, 2020·International Journal of Molecular Sciences·Ali H El-FarShaker A Mousa
Apr 10, 2019·Frontiers in Endocrinology·Martijn J L VerhulstWijnand J Teeuw
Oct 8, 2020·Molecular and Cellular Biochemistry·Bhargav N WaghelaChandramani Pathak

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