Advanced glycation end products, measured in skin, vs. HbA1c in children with type 1 diabetes mellitus

Pediatric Diabetes
Alena BanserMarja Mj van der Vorst

Abstract

Advanced glycation end products (AGEs) are considered major contributors to microvascular and macrovascular complications in adult patients with diabetes mellitus. AGEs can be measured non-invasively with skin autofluorescence (sAF). The primary aim was to determine sAF values in children with type 1 diabetes mellitus and to study correlations between sAF values and HbA1c and mean HbA1c over the year prior to measurement In children with type 1 diabetes mellitus, sAF values were measured using the AGE Reader®. Laboratory and anthropometric values were extracted from medical charts. Correlations were studied using Pearson's correlation coefficient. Multivariable linear regression analysis was conducted to evaluate the effect of multiple study parameters on sAF values. The mean sAF value was 1.33 ± 0.36 arbitrary units (AU) in children with type 1 diabetes mellitus (n = 144). sAF values correlated positively with HbA1c measured at the same time (r = 0.485; p < 0.001), mean HbA1c over the year prior to measurement (r = 0.578; p < 0.001), age (r = 0.337; p < 0.001), duration of type 1 diabetes mellitus (r = 0.277; p = 0.001), serum triglycerides (r = 0.399; p < 0.001), and total cholesterol (r = 0.352; p = 0.001). sAF values were s...Continue Reading

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Citations

Sep 3, 2016·Cardiovascular Diabetology·Fritz-Line Vélayoudom-CéphiseVincent Rigalleau
Oct 23, 2016·Diabetic Medicine : a Journal of the British Diabetic Association·Y H ChoK C Donaghue
Nov 16, 2019·Journal of Basic and Clinical Physiology and Pharmacology·Wei Zien GanRhun Yian Koh
May 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jonas WizentyTilo Wuensch
Jan 30, 2021·Journal of the American Society for Mass Spectrometry·Arvind M Korwar, Qibin Zhang

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