Advanced glycation end products regulate interleukin-1β production in human placenta

The Journal of Reproduction and Development
Kotomi SenoKoumei Shirasuna

Abstract

Maternal obesity is a major risk factor for pregnancy complications, causing inflammatory cytokine release in the placenta, including interleukin-1β (IL-1β), IL-6, and IL-8. Pregnant women with obesity develop accelerated systemic and placental inflammation with elevated circulating advanced glycation end products (AGEs). IL-1β is a pivotal inflammatory cytokine associated with obesity and pregnancy complications, and its production is regulated by NLR family pyrin domain-containing 3 (NLRP3) inflammasomes. Here, we investigated whether AGEs are involved in the activation of NLRP3 inflammasomes using human placental tissues and placental cell line. In human placental tissue cultures, AGEs significantly increased IL-1β secretion, as well as IL-1β and NLRP3 mRNA expression. In human placental cell culture, although AGE treatment did not stimulate IL-1β secretion, AGEs significantly increased IL-1β mRNA expression and intracellular IL-1β production. After pre-incubation with AGEs, nano-silica treatment (well known as an inflammasome activator) increased IL-1β secretion in placental cells. However, after pre-incubation with lipopolysaccharide to produce pro-IL-1β, AGE treatment did not affect IL-1β secretion in placental cells. The...Continue Reading

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Citations

Oct 21, 2017·The Journal of Biological Chemistry·Seunghwan SonJe-Wook Yu
Mar 29, 2019·Clinical and Experimental Immunology·N JaiswalA Agrawal
Dec 13, 2017·Oxidative Medicine and Cellular Longevity·Xiang KongQing Su
Nov 20, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nardhy Gomez-LopezRoberto Romero
Mar 13, 2020·Frontiers in Endocrinology·Koumei ShirasunaMasafumi Takahashi
Jul 26, 2019·Oxidative Medicine and Cellular Longevity·Sara MendesElisabete Silva
Aug 28, 2021·Nutrients·Ma Eugenia Garay-SevillaJaime Uribarri

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Datasets Mentioned

BETA
BC143363

Methods Mentioned

BETA
FCS
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

Image J

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