Advanced glycosylation end products up-regulate connective tissue growth factor (insulin-like growth factor-binding protein-related protein 2) in human fibroblasts: a potential mechanism for expansion of extracellular matrix in diabetes mellitus

Endocrinology
S M TwiggR G Rosenfeld

Abstract

Expansion of extracellular matrix with fibrosis occurs in many tissues as part of the end-organ complications in diabetes, and advanced glycosylation end products (AGE) are implicated as one causative factor in diabetic tissue fibrosis. Connective tissue growth factor (CTGF), also known as insulin-like growth factor-binding protein-related protein-2 (IGFBP-rP2), is a potent inducer of extracellular matrix synthesis and angiogenesis and is increased in tissues from rodent models of diabetes. The aim of this study was to determine whether CTGF is up-regulated by AGE in vitro and to explore the cellular mechanisms involved. AGE treatment of primary cultures of nonfetal human dermal fibroblasts in confluent monolayer increased CTGF steady state messenger RNA (mRNA) levels in a time- and dose-dependent manner. In contrast, mRNAs for other IGFBP superfamily members, IGFBP-rP1 (mac 25) and IGFBP-3, were not up-regulated by AGE. The effect of the AGE BSA reagent on CTGF mRNA was due to nonenzymatic glycosylation of BSA and, using neutralizing antisera to AGE and to the receptor for AGE, termed RAGE, was seen to be due to late products of nonenzymatic glycosylation and was partly mediated by RAGE. Reactive oxygen species as well as endo...Continue Reading

References

Mar 1, 1987·Journal of the American Academy of Dermatology·W HannaA Hanna
Nov 1, 1982·Arthritis and Rheumatism·J R Seibold
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·C W YangL J Striker
Jan 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·L J Striker, G E Striker
Mar 1, 1997·European Journal of Clinical Investigation·S D YanA M Schmidt
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·T KoschinskyH Vlassara
Jul 30, 1997·Biochemical and Biophysical Research Communications·C HirataM Kondo
Feb 14, 1998·Cytokine & Growth Factor Reviews·G R Grotendorst
Apr 29, 1998·The Journal of Clinical Investigation·M LuA P Adamis
Apr 29, 1998·Kidney International·Y ItoR Goldschmeding
Sep 23, 1998·The International Journal of Biochemistry & Cell Biology·J DammeierS Werner
Jul 15, 1999·The International Journal of Biochemistry & Cell Biology·R G Paul, A J Bailey
Feb 29, 2000·Metabolism: Clinical and Experimental·M Brownlee

❮ Previous
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Citations

Jul 20, 2004·The British Journal of Ophthalmology·E J KuiperR O Schlingemann
Jul 14, 2009·Arthritis Research & Therapy·Michele AbateRoberto Paganelli
May 14, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Esther J KuiperReinier O Schlingemann
Nov 5, 2008·Journal of Periodontology·Jesse MurilloBjorn Steffensen
Dec 10, 2009·World Journal of Gastroenterology : WJG·Christina LohwasserDetlef Schuppan
Dec 29, 2012·International Journal of Preventive Medicine·Zoya Tahergorabi, Majid Khazaei
Dec 12, 2012·Indian Journal of Endocrinology and Metabolism·Sunil K KotaKirtikumar D Modi
Apr 23, 2013·Life Sciences·Paulo Zoé Costa, Raquel Soares
Aug 12, 2014·Foot and Ankle Surgery : Official Journal of the European Society of Foot and Ankle Surgeons·Bruno MagnanElena Samaila
Jan 15, 2011·Journal of Cell Communication and Signaling·Stephen M Twigg
Jun 2, 2011·Journal of Cell Communication and Signaling·Xiaoyu WangStephen M Twigg
Mar 3, 2010·Journal of Cell Communication and Signaling·Xiaoyu WangStephen M Twigg
May 28, 2005·Progress in Retinal and Eye Research·B'Ann True Gabelt, Paul L Kaufman
Dec 26, 2013·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Tomohiro HikataMichihiro Kamata
Feb 5, 2013·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Tao-Hua LanHong-Mei Tan
Jun 6, 2003·Kidney International·Krystyna H ZarrinkalamRandall J Faull
May 11, 2005·Kidney International·Mingyu LiangJennifer L Pietrusz
Dec 2, 2008·Acta Physiologica·A DanielsF A van Nieuwenhoven
Mar 26, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Giuseppina BastaFranco Filipponi
May 2, 2008·Annals of the New York Academy of Sciences·Usman AhmedPaul J Thornalley
Mar 31, 2015·Experimental Eye Research·Ingeborg KlaassenReinier O Schlingemann
Mar 15, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Laure ElkriefRichard Moreau
May 25, 2007·Connective Tissue Research·Paul E NormanJonathan Golledge
Oct 28, 2006·Cornea·Maria João QuadradoJaap A Van Best
Nov 13, 2013·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Rob J Van GeestReinier O Schlingemann
Jun 16, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Rachael G DeanLouise M Burrell
Dec 25, 2002·Medicinal Research Reviews·Alexandra MartinDavid C Sane
May 25, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Anna SoliniFrancesco Di Virgilio
Apr 19, 2003·Circulation Research·David A Kass

❮ Previous
Next ❯

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