Advanced HIV disease in the Botswana combination prevention project: prevalence, risk factors, and outcomes.

AIDS
Refeletswe LebelonyaneJ N Jarvis

Abstract

To determine the proportion of individuals linking to HIV-care with advanced HIV-disease (CD4 cell counts ≤200 cells/μl) in the Botswana Combination Prevention Project, describe the characteristics of these individuals, and examine treatment outcomes. A subanalysis of a cluster-randomized HIV-prevention trial. HIV status was assessed in 16-64-year-olds through home and mobile testing. All HIV-positive persons not on antiretroviral therapy were referred to local Ministry of Health and Wellness clinics for treatment. Analysis was restricted to the 15 intervention clusters. The proportion of individuals with advanced HIV disease was determined; associations between advanced HIV disease and sex and age explored; and rates of viral suppression determined at 1-year. Mortality and retention in care were compared between CD4 strata (CD4 cell counts ≤200 vs. >200 cells/μl). Overall, 17.2% [430/2499; 95% confidence interval (CI) 15.7-18.8%] of study participants had advanced HIV disease (CD4 cell counts ≤200 cells/μl) at time of clinic linkage. Men were significantly more likely to present with CD4 cell counts 200 cells/μl or less than women [23.7 vs. 13.4%, adjusted odds ratio 1.9, 95% CI 1.5-2.3]. The risk of advanced HIV disease incre...Continue Reading

Associated Clinical Trials

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Sep 14, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Sarah WalkerUNKNOWN DART and ARROW trial teams
Apr 25, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gabriela E PattenLynne S Wilkinson
Aug 13, 2015·PloS One·Scott Dryden-PetersonShahin Lockman
May 16, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mark W TenfordeJoseph N Jarvis
Mar 8, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Meg OslerAndrew Boulle
Mar 8, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sergio CarmonaWilliam B MacLeod
Dec 15, 2018·Journal of the International AIDS Society·Chloe A TeasdaleWafaa M El-Sadr
Jul 18, 2019·The New England Journal of Medicine·Joseph MakhemaShahin Lockman
May 7, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Esther NasuunaJoanita Kigozi

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Citations

Nov 17, 2020·AIDS·Michael J Vinikoor, Lottie Hachaambwa
May 7, 2021·Current HIV/AIDS Reports·José A BauermeisterDovie Watson
Jul 18, 2021·AIDS Research and Therapy·Nadine Mayasi NgongoGilles Darcis
Jul 27, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nathan Ford, Tom Chiller

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