Advanced Human Immunodeficiency Virus Disease in Botswana Following Successful Antiretroviral Therapy Rollout: Incidence of and Temporal Trends in Cryptococcal Meningitis

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Mark W TenfordeJoseph N Jarvis

Abstract

Botswana has a well-developed antiretroviral therapy (ART) program that serves as a regional model. With wide ART availability, the burden of advanced human immunodeficiency virus (HIV) and associated opportunistic infections would be expected to decline. We performed a nationwide surveillance study to determine the national incidence of cryptococcal meningitis (CM), and describe characteristics of cases during 2000-2014 and temporal trends at 2 national referral hospitals. Cerebrospinal fluid data from all 37 laboratories performing meningitis diagnostics in Botswana were collected from the period 2000-2014 to identify cases of CM. Basic demographic and laboratory data were recorded. Complete national data from 2013-2014 were used to calculate national incidence using UNAIDS population estimates. Temporal trends in cases were derived from national referral centers in the period 2004-2014. A total of 5296 episodes of CM were observed in 4702 individuals; 60.6% were male, and median age was 36 years. Overall 2013-2014 incidence was 17.8 (95% confidence interval [CI], 16.6-19.2) cases per 100000 person-years. In the HIV-infected population, incidence was 96.8 (95% CI, 90.0-104.0) cases per 100000 person-years; male predominance w...Continue Reading

References

Mar 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D H MitchellT Gottlieb
Dec 20, 2007·AIDS·Joseph N Jarvis, Thomas S Harrison
May 11, 1946·Lancet
Mar 5, 2013·PloS One·Vasilios PyrgosPeter R Williamson
Aug 12, 2014·The Lancet Global Health·Mansour FarahaniRichard Marlink
May 6, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Matthew P Fox, Sydney Rosen
May 12, 2015·Current Tropical Medicine Reports·David MeyaJoseph N Jarvis
Mar 14, 2016·The Lancet Infectious Diseases·Joseph N Jarvis, Thomas S Harrison
Mar 14, 2016·The Lancet Infectious Diseases·Joshua RheinUNKNOWN ASTRO-CM Study Team
Apr 30, 2016·The Lancet. HIV·Salim Abdool Karim
Aug 2, 2016·The Lancet Infectious Diseases·James E ScrivenGraeme Meintjes
Aug 12, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Alana T BrennanMatthew P Fox

❮ Previous
Next ❯

Citations

May 10, 2017·The Lancet Infectious Diseases·Peter R Williamson
Mar 15, 2018·The New England Journal of Medicine·Síle F MolloyUNKNOWN ACTA Trial Study Team
Mar 8, 2018·Memórias do Instituto Oswaldo Cruz·Ahmad Mourad, John R Perfect
Mar 8, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lisa FrigatiNathan Ford
Aug 30, 2018·The Cochrane Database of Systematic Reviews·Ajibola A AwotiwonIngrid Eshun-Wilson
Mar 17, 2018·AIDS·Kiran T ThakurGretchen L Birbeck
Nov 14, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Diana FainiEmilio Letang
Jan 31, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph N Jarvis, Thomas S Harrison
Jul 2, 2019·The Pediatric Infectious Disease Journal·Hannah K MitchellMark W Tenforde
Apr 3, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·William J HurtJoseph N Jarvis
Jul 23, 2020·Molecular Microbiology·Arianne Bermas, Jennifer Geddes-McAlister
Jun 23, 2020·Expert Review of Anti-infective Therapy·Greg GreeneJoseph N Jarvis
Oct 30, 2019·Open Forum Infectious Diseases·Jayne EllisDavid R Boulware
Mar 14, 2019·Frontiers in Microbiology·Kiem VuAngie Gelli
Dec 7, 2018·Current Opinion in Infectious Diseases·David S LawrenceJoseph N Jarvis
Apr 19, 2018·Memórias do Instituto Oswaldo Cruz·Marcio L Rodrigues
Jul 6, 2019·F1000Research·Timothée Boyer-ChammardOlivier Lortholary
Nov 2, 2019·Bioorganic & Medicinal Chemistry Letters·Michael TrzossKaren Joy Shaw
Apr 20, 2021·The Lancet Infectious Diseases·Katharine Elizabeth StottWilliam Hope
May 22, 2021·Infectious Disease Clinics of North America·Emma E SeagleTom M Chiller

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

© 2022 Meta ULC. All rights reserved