Advanced MALDI mass spectrometry imaging in pharmaceutical research and drug development

Current Opinion in Biotechnology
Sandra SchulzCarsten Hopf

Abstract

Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) has emerged as a key technology for label-free bioanalysis of the spatial distribution of biomolecules, pharmaceuticals and other xenobiotics in tissue sections. Recent advances in instrumentation, sample preparation, multimodal workflows, quantification, analytical standardization and 'big data' processing have led to widespread utilization of MALDI MSI in pharmaceutical research. These developments have led to applications of the technology in drug discovery beyond drug disposition analysis, most notably in pharmacodynamic biomarker research and in toxicology.

Citations

Jul 23, 2019·Chemical Communications : Chem Comm·James E Kath, Aleksandra Baranczak
Aug 1, 2019·Natural Product Reports·Joseph E SprakerLaura M Sanchez
Dec 31, 2019·SLAS Discovery·Juliana Maynard, Philippa Hart
Feb 13, 2020·Bioinformatics·Katja OvchinnikovaTheodore Alexandrov
Jun 6, 2020·Mass Spectrometry Reviews·Enrico DavoliLavinia Morosi
Apr 8, 2020·Plant & Cell Physiology·Tomomi Morikawa-IchinoseAkiko Maruyama-Nakashita
Sep 30, 2020·Current Protocols in Pharmacology·Leandro L SantosBrandon G Santiago
Dec 15, 2018·Proteomics. Clinical Applications·Erin H Seeley
Jul 4, 2019·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Donglu ZhangS Cyrus Khojasteh
Apr 5, 2020·BMC Bioinformatics·Katja OvchinnikovaTheodore Alexandrov
Aug 11, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gemma CurrieChristian Delles
May 8, 2020·Foods·Yoshimura Yukihiro, Nobuhiro Zaima
Oct 14, 2020·Journal of Neurochemistry·Martina Blank, Carsten Hopf
Nov 12, 2020·Mass Spectrometry Reviews·Wendy H MüllerGauthier Eppe
Nov 11, 2020·Mass Spectrometry Reviews·Vladimir A AzovAlexander A Makarov
Jul 28, 2019·Pulmonary Pharmacology & Therapeutics·Maria Gabriella MateraMario Cazzola
Feb 2, 2021·Journal of the American Society for Mass Spectrometry·Benjamin BalluffRon M A Heeren
Feb 11, 2021·Analytical and Bioanalytical Chemistry·Jacob X M TruongPaul J Trim
Nov 4, 2020·Analytical and Bioanalytical Chemistry·Vilmos Kertesz, John F Cahill
Nov 21, 2020·Analytical and Bioanalytical Chemistry·Qiuqin ZhouCarsten Hopf
Feb 17, 2021·Bioscience, Biotechnology, and Biochemistry·Yoshimichi SakakibaraKengo Shigetomi
Jan 29, 2021·Scientific Reports·Miaomiao LiuRonald J Quinn
Mar 2, 2021·Analytical and Bioanalytical Chemistry·Wanqiu ZhangNico Verbeeck
Mar 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Margaux FresnaisRémi Longuespée
Mar 4, 2021·Journal of Cosmetic Dermatology·Xueqing Hu, Huaming He
Sep 4, 2020·British Journal of Clinical Pharmacology·Rémi LonguespéeWalter E Haefeli
Feb 26, 2021·Drug Metabolism and Pharmacokinetics·Daisuke SaigusaSeizo Koshiba
Mar 13, 2021·Frontiers in Bioengineering and Biotechnology·Bashar Amer, Edward E K Baidoo
Mar 17, 2021·Journal of Mass Spectrometry : JMS·Stephen CastellinoMark Reid Groseclose
Mar 18, 2021·Advanced Biology·Carina RamalloGuevaraPavel A Levkin
May 1, 2021·Antibody Therapeutics·Mahendra P Deonarain, Quinn Xue

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