Advanced molecular surveillance of hepatitis C virus

Viruses
Livia Maria Gonçalves RossiPaula Rahal

Abstract

Hepatitis C virus (HCV) infection is an important public health problem worldwide. HCV exploits complex molecular mechanisms, which result in a high degree of intrahost genetic heterogeneity. This high degree of variability represents a challenge for the accurate establishment of genetic relatedness between cases and complicates the identification of sources of infection. Tracking HCV infections is crucial for the elucidation of routes of transmission in a variety of settings. Therefore, implementation of HCV advanced molecular surveillance (AMS) is essential for disease control. Accounting for virulence is also important for HCV AMS and both viral and host factors contribute to the disease outcome. Therefore, HCV AMS requires the incorporation of host factors as an integral component of the algorithms used to monitor disease occurrence. Importantly, implementation of comprehensive global databases and data mining are also needed for the proper study of the mechanisms responsible for HCV transmission. Here, we review molecular aspects associated with HCV transmission, as well as the most recent technological advances used for virus and host characterization. Additionally, the cornerstone discoveries that have defined the pathwa...Continue Reading

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Citations

Jan 7, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Livia Maria Gonçalves RossiPaula Rahal
Oct 5, 2017·Nucleic Acids Research·Konstantinos KaragiannisRaja Mazumder
Apr 26, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Heidar SharafiSeyed Moayed Alavian

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Methods Mentioned

BETA
PCR
genotyping
Gel Shift
electrophoresis
amplicon sequencing
glycosylation

Software Mentioned

convert
SeqPublish
Treemaker
ViPR
Gene Cutter
Seq
Modeltest
PeptGen
PCOORD
MEGA5

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