Advanced nanomedicines for the treatment of inflammatory diseases.

Advanced Drug Delivery Reviews
Romain BrusiniPatrick Couvreur

Abstract

Inflammation, a common feature of many diseases, is an essential immune response that enables survival and maintains tissue homeostasis. However, in some conditions, the inflammatory process becomes detrimental, contributing to the pathogenesis of a disease. Targeting inflammation by using nanomedicines (i.e. nanoparticles loaded with a therapeutic active principle), either through the recognition of molecules overexpressed onto the surface of activated macrophages or endothelial cells, or through enhanced vasculature permeability, or even through biomimicry, offers a promising solution for the treatment of inflammatory diseases. After providing a brief insight on the pathophysiology of inflammation and current therapeutic strategies, the review will discuss, at a pre-clinical stage, the main innovative nanomedicine approaches that have been proposed in the past five years for the resolution of inflammatory disorders, finally focusing on those currently in clinical trials.

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Citations

Oct 1, 2020·Journal of Drug Targeting·Zaynab Sadeghi-GhadiAli Nokhodchi
Jan 7, 2021·Expert Opinion on Drug Delivery·Andrea PerrelliSaverio Francesco Retta
Jan 8, 2021·Pharmaceutics·Susana Barbosa RibeiroCaroline Addison Carvalho Xavier de Medeiros
Sep 11, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yin DouJianxiang Zhang
Apr 17, 2021·Drug Delivery and Translational Research·Zhengyu Deng, Shiyong Liu
Apr 24, 2021·International Journal of Biological Macromolecules·Yan PengZhi Li
Apr 23, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Guangshuai ZhangQiang Fu
Apr 30, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·P Couvreur
May 28, 2021·AAPS PharmSciTech·Prativa BiswasroyGoutam Rath
May 18, 2021·Acta Pharmaceutica Sinica. B·Qingqing XiaoWei He
Jun 12, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Fátima Fernández-ÁlvarezJosé L Arias
Jul 18, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Nian LiuXiaopeng Ma

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Methods Mentioned

BETA
transfection
transgenic

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