Advanced oxidation protein products aggravate cardiac remodeling via cardiomyocyte apoptosis in chronic kidney disease

American Journal of Physiology. Heart and Circulatory Physiology
Weijing FengHui Huang

Abstract

Advanced oxidation protein products (AOPPs) are independent risk factor for various cardiovascular diseases. Cardiomyocyte apoptosis has been implicated as an important mechanism in cardiac remodeling in chronic kidney disease (CKD). However, whether AOPPs affect cardiomyocyte apoptosis and subsequent cardiac remodeling in CKD is still not very clear. Here, we assessed the role of AOPPs in cardiomyocyte apoptosis in CKD. H9C2 rat cardiomyoblast cells were exposed to AOPPs. Apoptotic cells were determined by TUNEL assay. The expression of apoptotic markers (cleaved caspase-3 and Bax), JNK signaling, and endoplasmic reticulum stress were explored. Serum AOPPs were measured in male Sprague-Dawley rats that underwent sham surgery and 5/6 nephrectomy, respectively. In vitro, our findings showed that AOPPs activated JNK signaling and endoplasmic reticulum stress and significantly aggravated H9C2 rat cardiomyoblast cells apoptosis. These effects were partially ameliorated by apocynin with inhibition of oxidative stress. In vivo, serum levels of AOPPs were progressively elevated with the increasing time course in CKD rats compared with sham-operated rats ( P < 0.05). Serum AOPP levels were positively associated with cardiomyocyte apopt...Continue Reading

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Citations

Oct 12, 2018·Clinical and Molecular Allergy : CMA·Luisa RicciardiSebastiano Gangemi
Mar 11, 2020·Toxins·Nadine KaeslerRafael Kramann
Aug 15, 2018·Journal of Clinical Medicine·Mateusz MaciejczykAnna Zalewska
Mar 26, 2021·Oxidative Medicine and Cellular Longevity·Kacper Maksymilian MilMateusz Maciejczyk
Apr 2, 2021·International Journal of Cardiology·Ampadu O JacksonShiyin Long

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

SPSS
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