Advanced oxidation protein products in obese women: its relation to insulin resistance and resistin

Clinical and Experimental Medicine
H KoçakH Işsever

Abstract

Obesity is a major risk factor for insulin resistance and type 2 diabetes mellitus (T2DM). Resistin, an adipocyte-secreted hormone, is thought to take a part in the development of insulin resistance and T2DM. The aim of this study was to characterise the changes in circulating levels of resistin and proinflammatory cytokines tumour necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in diabetic and prediabetic obese patients and to explore their relationship to insulin resistance. Attempts were also made to see whether resistin levels are related to the degree of oxidative stress, as determined by the measurement of advanced oxidation protein products (AOPPs). The study groups consisted of obese diabetic (BMI: 30-42 kg/m(2), n=28) and prediabetic (BMI: 29-41 kg/m(2), n=23) women. Fourteen healthy women, with BMI in the range 21.5-25.5 kg/m(2), were taken as controls. Serum levels of TNF-a, IL-6, resistin, glucose, insulin and AOPPs were measured. Insulin resistance was calculated by the homeostasis model assessment (HOMA-IR). Diabetic and prediabetic obese patients had increases in serum resistin and TNF-alpha levels (P<0.01 and P<0.001, respectively). IL-6 levels in diabetic patients were significantly higher than in pred...Continue Reading

References

Oct 1, 1994·The Journal of Clinical Investigation·G S HotamisligilB M Spiegelman
May 1, 1996·Kidney International·V Witko-SarsatB Descamps-Latscha
Nov 18, 2000·Metabolism: Clinical and Experimental·N MitoK Sato
Feb 24, 2001·Nature·C M SteppanM A Lazar
May 7, 2002·The Journal of the Royal Society for the Promotion of Health·E C Opara
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·R De CristofaroG Davì
Sep 27, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·J-L ZhangD-J Zou
Sep 30, 2003·European Journal of Endocrinology·Josef V SilhaLiam J Murphy
Feb 28, 2004·Diabetes·Frank B HuJoAnn E Manson
Nov 9, 2004·Journal of Diabetes and Its Complications·Hillary A TuttlePaul F McDonagh
Dec 16, 2004·The Journal of Clinical Investigation·Shigetada FurukawaIichiro Shimomura
Jan 15, 2005·Antioxidants & Redox Signaling·Giovanni DavìCarlo Patrono
Feb 3, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lizette Gil-del ValleMaria A Otero
May 4, 2005·The Journal of Allergy and Clinical Immunology·Giamila Fantuzzi
May 6, 2005·Journal of Vascular Surgery·Panagiotis KougiasChangyi Chen
Jul 2, 2005·Diabetes/metabolism Research and Reviews·Ake Sjöholm, Thomas Nyström
Jul 27, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S BoG F Pagano
Aug 18, 2005·Clinical Science·Christine M KusminskiSudhesh Kumar
Oct 18, 2005·Alimentary Pharmacology & Therapeutics·R VettorG Federspil
May 20, 2006·European Journal of Pediatrics·M Emre AtabekSelim Kurtoglu
Oct 19, 2006·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Siriporn ChanchayChusak Varongchayakul
Oct 27, 2006·Diabetes·Yong QiRexford S Ahima
Dec 29, 2006·Diabetes Care·UNKNOWN American Diabetes Association

❮ Previous
Next ❯

Citations

Dec 10, 2013·Experimental Gerontology·Ji-Huan ZengJian-Ting Chen
Mar 3, 2009·Vitamins and Hormones·Jeong-Ho KimJie Chen
Sep 20, 2008·Physical Therapy·Lisa Stehno-Bittel
Jul 5, 2019·Physiology International·C C CallegaroJ A Taylor
Dec 8, 2010·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Yuan-Han ChenXia Fu
Jan 6, 2021·Molecular and Cellular Biochemistry·Ma Eugenia Garay-SevillaArmando Rojas
May 28, 2021·Journal of Assisted Reproduction and Genetics·Aalaap NaigaonkarSrabani Mukherjee
Oct 1, 2018·Free Radical Biology & Medicine·Lucas Kich GrunFlorencia María Barbé-Tuana

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Jing ZhangLiangzhi Xu
The Journal of Clinical Investigation
Stuart P WeisbergAnthony W Ferrante
JAMA : the Journal of the American Medical Association
A D PradhanP M Ridker
© 2021 Meta ULC. All rights reserved