Advanced periocular basal cell carcinoma-a therapeutic challenge

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
B LauterbachE S Schultz

Abstract

Basal cell carcinomas are the most common periocular malignant tumor. In advanced periocular basal cell carcinoma, vismodegib is a new treatment option which might potentially avoid surgical eye removal. We treated a 76-year-old patient unwilling to consent to surgery with vismodegib for advanced periocular basal cell carcinoma on the left forehead that had already undergone several previous treatments. After initial partial remission, the tumor regrew under ongoing therapy, so that radical surgical excision including orbital exenteration was performed. Unfortunately, the patient died thereafter due to septic multi-organ failure. Basal cell carcinoma and its new treatment options are gaining importance for ophthalmology due to rising incidence and prevalence rates. Vismodegib is a new encouraging option. However, for advanced tumors, it must be resolved whether complete histological remission may be achieved to avoid surgical intervention, or whether the area of resection can be significantly reduced. Current multicenter studies investigate these aspects further (ClinicalTrails.gov identifier: NCT03035188).

References

Dec 1, 1982·American Journal of Clinical Oncology·M M OkenP P Carbone
Jun 8, 2012·The New England Journal of Medicine·Aleksandar SekulicAxel Hauschild
Aug 23, 2012·Archives of Dermatology·Anne Lynn S Chang, Anthony E Oro
Oct 19, 2013·JAMA Ophthalmology·Harmeet S GillRona Z Silkiss
Jun 16, 2014·Journal of the American Academy of Dermatology·Mina Sarah AllyJean Yuh Tang
Feb 13, 2015·Ophthalmic Plastic and Reconstructive Surgery·Hakan DemirciAlon Kahana
Feb 26, 2016·JAMA Dermatology·Albert RübbenMartin Leverkus
Oct 19, 2016·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·V KakkasseryL M Heindl
Jan 31, 2017·Klinische Monatsblätter für Augenheilkunde·M KeserüS Dulz
Oct 11, 2017·Klinische Monatsblätter für Augenheilkunde·Vinodh Kakkassery, Ludwig M Heindl
Oct 27, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N Basset-SéguinJ Hansson

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Citations

Sep 29, 2019·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·A C RokohlL M Heindl
Jul 31, 2019·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Alexander C RokohlLudwig M Heindl
Dec 8, 2019·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Vinodh KakkasseryLudwig M Heindl
Aug 3, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Alexander C Rokohl, Ludwig M Heindl

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