Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone

PloS One
Daniela OhdeAndreas Hoeflich

Abstract

Long-term-selected DUhTP mice represent a non-inbred model for inborn physical high-performance without previous training. Abundance of hepatic mRNA in 70-day male DUhTP and control mice was analyzed using the Affymetrix mouse array 430A 2.0. Differential expression analysis with PLIER corrected data was performed using AltAnalyze. Searching for over-representation in biochemical pathways revealed cholesterol metabolism being most prominently affected in DUhTP compared to unselected control mice. Furthermore, pathway analysis by AltAnalyze plus PathVisio indicated significant induction of glycolysis, fatty acid synthesis and cholesterol biosynthesis in the liver of DUhTP mice versus unselected control mice. In contrast, gluconeogenesis was partially inactivated as judged from the analysis of hepatic mRNA transcript abundance in DUhTP mice. Analysis of mRNA transcripts related to steroid hormone metabolism inferred elevated synthesis of progesterone and reduced levels of sex steroids. Abundance of steroid delta isomerase-5 mRNA (Hsd3b5, FC 4.97) was increased and steroid 17-alpha-monooxygenase mRNA (Cyp17a1, FC -11.6) was massively diminished in the liver of DUhTP mice. Assessment of steroid profiles by LC-MS revealed increased ...Continue Reading

References

Sep 1, 1979·European Journal of Applied Physiology and Occupational Physiology·A BonenA N Belcastro
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M A MagnusonD K Granner
Jan 1, 1985·European Journal of Applied Physiology and Occupational Physiology·D JezováS Kozlowski
Jul 1, 1993·The Biochemical Journal·P B Iynedjian
Jul 22, 1998·Behavior Genetics·J G SwallowT Garland
Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
Jan 26, 2000·Metabolism: Clinical and Experimental·A R CogganC W Yeckel
Feb 13, 2001·Physiological Genomics·L G Koch, S L Britton
Jun 22, 2001·Journal of Chromatography. B, Biomedical Sciences and Applications·A MarwahH Lardy
May 8, 2002·The Journal of Clinical Investigation·Jay D HortonMichael S Brown
Jan 5, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·R Scott RectorJamal A Ibdah
Jan 18, 2008·Physiological and Biochemical Zoology : PBZ·Lobke M VaanholtG Henk Visser
Mar 18, 2008·American Journal of Clinical Pathology·Mark M KushnirA Wayne Meikle
Jul 25, 2008·The Biochemical Journal·Loranne Agius
Aug 30, 2008·Cellular and Molecular Life Sciences : CMLS·P B Iynedjian
Sep 27, 2008·BMC Bioinformatics·Martijn P van IerselChris Evelo
Jun 9, 2009·PloS One·Jingjing GuEmmeline W Hill
Jul 17, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T SeifertH B Nielsen
Jun 2, 2010·Nucleic Acids Research·Dorothea EmigMario Albrecht
Nov 13, 2010·Nucleic Acids Research·Ethan G CeramiChris Sander
Feb 18, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Wee Kian YeoJohn A Hawley
Jun 21, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Pekka Keski-RahkonenSeppo Auriola
Nov 19, 2011·Nucleic Acids Research·Thomas KelderAlexander R Pico
May 1, 2012·Journal of Nutrition and Metabolism·Fábio S LiraMarília Seelaender
May 11, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nicole M TemplemanGrant B McClelland
Jul 21, 2012·BMC Medicine·Andrew Murray, Ricardo J S Costa
Nov 20, 2012·Nucleic Acids Research·J A BlakeM Westerfield
Dec 19, 2012·Medicine and Science in Sports and Exercise·Julia BrenmoehlAndreas Hoeflich
Dec 29, 2012·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ramakrishna NirogiSrinivasarao Gorentla
Jul 11, 2014·International Journal of Sports Physiology and Performance·Sian V AllenWill G Hopkins
Aug 22, 2014·Clinical and Experimental Pharmacology & Physiology·John A Hawley, James P Morton
May 6, 2015·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Sigal Ben-ZakenAlon Eliakim
Sep 13, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Meagan M WasfyAaron L Baggish
Nov 26, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Martin KunzeAndreas Hoeflich

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Citations

Nov 3, 2016·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Daniela OhdeAndreas Hoeflich
Jun 9, 2021·Indian Journal of Pharmacology·J KumaravelBikash Medhi

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Datasets Mentioned

BETA
GSE73539

Methods Mentioned

BETA
electrophoresis
PCR
Chip

Software Mentioned

PathVisio
AltAnalyze
Array Assist
PANTHER
Affymetrix GCOS
MAS ( Microarray Suite )

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