Advanced Small Animal Conformal Radiation Therapy Device

Technology in Cancer Research & Treatment
Sunil SharmaRobert J Griffin

Abstract

We have developed a small animal conformal radiation therapy device that provides a degree of geometrical/anatomical targeting comparable to what is achievable in a commercial animal irradiator. small animal conformal radiation therapy device is capable of producing precise and accurate conformal delivery of radiation to target as well as for imaging small animals. The small animal conformal radiation therapy device uses an X-ray tube, a robotic animal position system, and a digital imager. The system is in a steel enclosure with adequate lead shielding following National Council on Radiation Protection and Measurements 49 guidelines and verified with Geiger-Mueller survey meter. The X-ray source is calibrated following AAPM TG-61 specifications and mounted at 101.6 cm from the floor, which is a primary barrier. The X-ray tube is mounted on a custom-made "gantry" and has a special collimating assembly system that allows field size between 0.5 mm and 20 cm at isocenter. Three-dimensional imaging can be performed to aid target localization using the same X-ray source at custom settings and an in-house reconstruction software. The small animal conformal radiation therapy device thus provides an excellent integrated system to promo...Continue Reading

References

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Citations

Mar 31, 2017·Technology in Cancer Research & Treatment·Sunil SharmaRobert J Griffin
Feb 15, 2020·Cancers·Rachel A SchlaakCarmen Bergom
Mar 13, 2020·Journal of Biophotonics·Antonello E SpinelliFederico Boschi
Apr 7, 2017·Physics in Medicine and Biology·Erin B AdamsonSean B Fain

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Methods Mentioned

BETA
imaging techniques
irradiate
X-ray

Software Mentioned

SACRTD
SACTRD
MATLAB

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