Advanced Ultrasound Technologies for Diagnosis and Therapy

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Anne RixFabian Kiessling

Abstract

Ultrasound is among the most rapidly advancing imaging techniques. Functional methods such as elastography have been clinically introduced, and tissue characterization is improved by contrast-enhanced scans. Here, novel superresolution techniques provide unique morphologic and functional insights into tissue vascularization. Functional analyses are complemented by molecular ultrasound imaging, to visualize markers of inflammation and angiogenesis. The full potential of diagnostic ultrasound may become apparent by integrating these multiple imaging features in radiomics approaches. Emerging interest in ultrasound also results from its therapeutic potential. Various applications of tumor ablation with high-intensity focused ultrasound are being clinically evaluated, and its performance strongly benefits from the integration into MRI. Additionally, oscillating microbubbles mediate sonoporation to open biologic barriers, thus improving the delivery of drugs or nucleic acids that are coadministered or coformulated with microbubbles. This article provides an overview of recent developments in diagnostic and therapeutic ultrasound, highlighting multiple innovation tracks and their translational potential.

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Citations

Nov 13, 2018·Expert Opinion on Drug Delivery·Sofie SnipstadTwan Lammers
Dec 12, 2019·Frontiers in Bioengineering and Biotechnology·Priyanka TharkarWojciech Chrzanowski
Oct 31, 2019·BioMed Research International·Qian GongChuanpin Chen
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Dec 2, 2021·Nano Convergence·Sinan Sabuncu, Adem Yildirim

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