Advancements in Developing Strategies for Sterilizing and Functional HIV Cures.

BioMed Research International
Wei XuLu Lu

Abstract

Combined antiretroviral therapy (cART) has been successful in prolonging lifespan and reducing mortality of patients infected with human immunodeficiency virus (HIV). However, the eradication of latent HIV reservoirs remains a challenge for curing HIV infection (HIV cure) because of HIV latency in primary memory CD4+ T cells. Currently, two types of HIV cures are in development: a "sterilizing cure" and a "functional cure." A sterilizing cure refers to the complete elimination of replication-competent proviruses in the body, while a functional cure refers to the long-term control of HIV replication without treatment. Based on these concepts, significant progress has been made in different areas. This review focuses on recent advancements and future prospects for HIV cures.

References

Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·T W ChunA S Fauci
May 29, 1999·The New England Journal of Medicine·J LisziewiczF Lori
Aug 16, 2005·Lancet·Ginger LehrmanDavid M Margolis
Apr 19, 2008·The Journal of Infectious Diseases·Shailesh K ChoudharyDavid M Margolis
Oct 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Weizao ChenDimiter S Dimitrov
Feb 12, 2009·Expert Reviews in Molecular Medicine·Mary-Catherine BowmanDavid M Margolis
Feb 14, 2009·The New England Journal of Medicine·Gero HütterEckhard Thiel
Apr 3, 2009·Current Opinion in HIV and AIDS·Amalio Telenti
May 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Elisabetta BianchiPeter S Kim
Sep 28, 2010·Nature·Panagis FilippakopoulosJames E Bradner
Oct 15, 2010·Virology Journal·Guerau Fernandez, Steven L Zeichner
Mar 23, 2011·Molecular Medicine·Shay MatalonCharles A Dinarello
Apr 20, 2011·Current Opinion in HIV and AIDS·Jason F Okulicz, Olivier Lambotte
Nov 16, 2011·Immunology and Cell Biology·Fiona WightmanSharon R Lewin
Dec 6, 2011·Nature·Alejandro B BalazsDavid Baltimore
Jan 13, 2012·Journal of Virology·Daniel A DonahueMark A Wainberg
Feb 11, 2012·Cellular and Molecular Life Sciences : CMLS·Kenichi ImaiTakashi Okamoto
Jul 7, 2012·Cytokine & Growth Factor Reviews·Anna Lisa RemoliMarco Sgarbanti
Aug 8, 2012·Trends in Immunology·Christine M DurandRobert F Siliciano
Mar 20, 2013·BMJ : British Medical Journal·Zosia Kmietowicz
Apr 17, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Lijing LiDavid L DiGiusto
Apr 17, 2013·Blood·Claire VandergeetenNicolas Chomont
Sep 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Joshua A HorwitzMichel C Nussenzweig
Oct 25, 2013·Lancet·Steven G DeeksDiane V Havlir

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Citations

Jul 16, 2020·Pharmaceutics·Alba Martín-MorenoMaría Angeles Muñoz-Fernández
Nov 12, 2019·Frontiers in Immunology·Alba Martín-Moreno, Mª Angeles Muñoz-Fernández
Mar 21, 2020·Frontiers in Immunology·Amit Kumar SinghVainav Patel
May 29, 2020·Antioxidants & Redox Signaling·Zeyu CaiWei Kong
Jun 28, 2018·Frontiers in Pharmacology·Arun K DangiPratyoosh Shukla
Jan 14, 2021·Journal of Virus Eradication·Evelyn Y BonneyUNKNOWN H-CRIS Massive Action Team

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