Advances and prospects of Bacillus subtilis cellular factories: From rational design to industrial applications

Metabolic Engineering
Long LiuLong Liu

Abstract

Bacillus subtilis is the most characterized gram-positive bacterium that has significant attributes, such as growing well on cheap carbon sources, possessing clear inherited backgrounds, having mature genetic manipulation methods, and exhibiting robustness in large-scale fermentations. Till date, B. subtilis has been identified as attractive hosts for the production of recombinant proteins and chemicals. By applying various systems and synthetic biology tools, the productivity features of B. subtilis can be thoroughly analyzed and further optimized via metabolic engineering. In the present review, we discussed why B. subtilis is the primary organisms used for metabolic engineering and industrial applications. Additionally, we summarized the recent advances in systems and synthetic biology, engineering strategies for improving cellular performances, and metabolic engineering applications of B. subtilis. In particular, we proposed emerging opportunities and essential strategies to enable the successful development of B. subtilis as microbial cell factories.

References

May 10, 2000·Nature Biotechnology·W R Farmer, J C Liao
Jan 11, 2000·Nucleic Acids Research·T IshiiK Nakai
Oct 9, 2002·Molecular Microbiology·Céline FabretPhilippe Noirot
Aug 5, 2003·Journal of Bacteriology·Akram Atalla, Wolfgang Schumann
Aug 9, 2003·Antonie van Leeuwenhoek·Bastiaan P KromJuke S Lolkema
Jun 10, 2004·Microbiology and Molecular Biology Reviews : MMBR·Harold TjalsmaJan Maarten van Dijl
Dec 3, 2004·Applied and Environmental Microbiology·Alain BransBernard Joris
Jul 8, 2005·Applied and Environmental Microbiology·Bill WidnerSteve Brown
Jul 8, 2005·Applied and Environmental Microbiology·Xiao-Zhou ZhangShun-Peng Li
Aug 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hal AlperGregory Stephanopoulos
Jul 11, 2006·European Journal of Cell Biology·Robert SternKazuki N Sugahara
Dec 13, 2006·Microbiology and Molecular Biology Reviews : MMBR·Josef DeutscherPieter W Postma
Nov 6, 2007·Nature Reviews. Microbiology·Abraham L Sonenshein
Mar 13, 2008·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Takuya MorimotoNaotake Ogasawara
Apr 9, 2008·Microbial Cell Factories·Jessica C ZweersJan Maarten van Dijl
Jun 28, 2008·Metabolic Engineering·Simon TännlerUwe Sauer
Jul 22, 2008·Applied and Environmental Microbiology·Xin YanShun-Peng Li
Jun 27, 2009·Genome Biology·Christopher S HenryRick L Stevens
Aug 4, 2009·Nature Biotechnology·John E DueberJay D Keasling
Sep 26, 2009·Applied Microbiology and Biotechnology·Yun Xia DuanXue Ming Zhao
Feb 13, 2010·Biotechnology Journal·John Blazeck, Hal Alper
Dec 15, 2010·Applied and Environmental Microbiology·Line AlbertsenUffe H Mortensen
Jan 25, 2011·Microbial Biotechnology·Xiao-Zhou Zhang, Y -H Percival Zhang
May 11, 2011·Molecular Systems Biology·Mary J DunlopAindrila Mukhopadhyay
May 24, 2011·Nature Chemical Biology·Harry YimStephen Van Dien
Oct 25, 2011·Applied and Environmental Microbiology·Darmawi JuminagaJay D Keasling
Oct 25, 2011·Nucleic Acids Research·Robert J ConradoMatthew P DeLisa
Nov 25, 2011·Applied and Environmental Microbiology·Liuyang DiaoRoland Freudl
Dec 14, 2011·Nature Biotechnology·Deepak Dugar, Gregory Stephanopoulos
Jan 11, 2012·Molecular Microbiology·Natalie JahnSabine Brantl
Jan 28, 2012·Journal of the American Chemical Society·Yongjin J ZhouZongbao K Zhao
Mar 1, 2012·Applied Microbiology and Biotechnology·Ranjita BiswasAkihiko Kondo
Mar 17, 2012·Nucleic Acids Research·Yang WangQirong Shen
May 19, 2012·Nature Chemical Biology·Jeong Wook LeeSang Yup Lee

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Citations

Aug 11, 2018·Biotechnology & Genetic Engineering Reviews·Jianguo Zhang, Nana Lan
Mar 18, 2020·Critical Reviews in Food Science and Nutrition·Muhammad BilalHairong Cheng
Sep 20, 2020·World Journal of Microbiology & Biotechnology·Ruangurai PromchaiPlearnpis Luxananil
Nov 7, 2019·Applied Microbiology and Biotechnology·Kelly K Miller, Hal S Alper
Sep 9, 2020·Nature Chemical Biology·Xianhao XuLong Liu
Oct 31, 2019·AIMS Microbiology·Alexandra SoaresFilipe J Mergulhão
Jun 28, 2019·Essays in Biochemistry·Sophie LandonClaire Grierson
Jun 3, 2020·Microbiology·Gavin H Thomas
Aug 9, 2020·Microbiology Resource Announcements·Björn RichtsFabian M Commichau
Aug 30, 2019·Environmental Science and Pollution Research International·Tania Patricia Santiago BadilloAntonio Avalos Ramirez
Oct 13, 2020·Nucleic Acids Research·Kevin RychelBernhard O Palsson
Oct 25, 2020·Journal of Applied Microbiology·H PramastyaW J Quax
Dec 15, 2020·Nature Communications·Kevin RychelBernhard O Palsson
Feb 25, 2021·Critical Reviews in Biotechnology·Seo A ParkKwon-Young Choi
Feb 8, 2020·Trends in Biotechnology·Xianhao XuLong Liu
Apr 16, 2021·World Journal of Microbiology & Biotechnology·Zhenqiang JiangShaoqing Yang
May 18, 2021·Journal of Bioscience and Bioengineering·Ming-Zhi Cai, Po-Ting Chen
Jul 20, 2021·Synthetic and Systems Biotechnology·Liang XiangJunbiao Dai
Sep 2, 2021·Applied Microbiology and Biotechnology·Haiquan YangXianzhong Chen

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