Advances in 3D neural, vascular and neurovascular models for drug testing and regenerative medicine.

Drug Discovery Today
Diogo C FernandesJ Miguel Oliveira

Abstract

Clinical trials continue to fall short regarding drugs to effectively treat brain-affecting diseases. Although there are many causes of these shortcomings, the most relevant are the inability of most therapeutic agents to cross the blood-brain barrier (BBB) and the failure to translate effects from animal models to patients. In this review, we analyze the most recent developments in BBB, neural, and neurovascular models, analyzing their impact on the drug development process by considering their quantitative and phenotypical characterization. We offer a perspective of the state-of-the-art of the models that could revolutionize the pharmaceutical industry.

References

Jul 1, 1992·Trends in Neurosciences·J DeFelipe, E G Jones
May 1, 1985·The American Journal of Physiology·W G Mayhan, D D Heistad
Jun 3, 1982·Brain Research·C Crone, S P Olesen
Jul 1, 1996·Glycobiology·E Ruoslahti
Mar 21, 2003·Virchows Archiv : an International Journal of Pathology·Rodolfo MontironiTheodorus Kwast
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·William M Pardridge
Dec 7, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Bojana StefanovicAfonso C Silva
May 20, 2008·Journal of Alzheimer's Disease : JAD·Claudia Schwab, Patrick L McGeer
Feb 20, 2009·The Journal of Comparative Neurology·Frederico A C AzevedoSuzana Herculano-Houzel
Mar 18, 2009·The Journal of Pathology·Peter W HamiltonAnthony G Gallagher
Nov 6, 2009·Thyroid : Official Journal of the American Thyroid Association·Sandra LassallePaul Hofman
Mar 3, 2010·Molecular Neurobiology·Guy C Brown, Jonas J Neher
Mar 13, 2012·Neuron·Christine Grienberger, Arthur Konnerth
Dec 7, 2013·Nature Medicine·Birgit ObermeierRichard M Ransohoff
Sep 5, 2014·Nature Protocols·Madeline A Lancaster, Juergen A Knoblich
Oct 4, 2014·Clinical Epidemiology·Anoushka SinghMichael G Fehlings
Jan 15, 2015·Journal of Laboratory Automation·Balaji SrinivasanJames J Hickman
Oct 20, 2015·Journal of the Neurological Sciences·Franc LlorensInga Zerr
Feb 11, 2016·Advances in Wound Care·Amanda S MacLeod, Jonathan N Mansbridge
Mar 2, 2016·Journal of Health Economics·Joseph A DiMasiRonald W Hansen
Jul 12, 2016·Biotechnology and Bioengineering·Ying I WangMichael L Shuler
Nov 3, 2016·Annals of Neurology·Silvia CasarottoMarcello Massimini
Nov 12, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Franciska ErdőElizabeth de Lange
Feb 2, 2017·Journal of Neuroscience Methods·Molly E BoutinDiane Hoffman-Kim
Apr 19, 2017·Stem Cell Reports·Anna S MonzelJens C Schwamborn
Apr 30, 2017·Neuropathology and Applied Neurobiology·E F GoodallS B Wharton
Jun 1, 2017·Nature Biotechnology·Madeline A LancasterJuergen A Knoblich
Jun 7, 2017·Nature Communications·Choi-Fong ChoSean E Lawler
Jun 20, 2017·Biochimica Et Biophysica Acta. General Subjects·Shinji Miyata, Hiroshi Kitagawa
Aug 6, 2017·Neurobiology of Aging·Tobias SkillbäckHenrik Zetterberg
Sep 6, 2017·Journal of Chemical Neuroanatomy·Christopher S von Bartheld
Oct 11, 2017·Stroke and Vascular Neurology·Pablo J BlancoJ David Spence
Oct 19, 2017·Journal for Immunotherapy of Cancer·Louise M E JanssenWillem W Overwijk
Nov 23, 2017·Frontiers in Neuroanatomy·Gordon M Shepherd, Timothy B Rowe

❮ Previous
Next ❯

Citations

Sep 16, 2021·Emerging Topics in Life Sciences·Paige A WalczakEric James Hill

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.