Advances in adoptive immunotherapy to accelerate T-cellular immune reconstitution after HLA-incompatible hematopoietic stem cell transplantation

Immunotherapy
Christian ReimannMarina Cavazzana-Calvo

Abstract

Although partially HLA-mismatched hematopoietic stem cell transplantation (HSCT) has become an important therapeutic option for children with primary immunodeficiencies, delayed reconstitution of the T-cell compartment remains a major clinical concern. Adoptive immunotherapies to provide recipients with a protective and diverse T-cell repertoire in the months following HSCT are warranted. In order to improve T-cell reconstitution after T-cell-depleted HSCT, different strategies are currently being studied. Some are based on administration of modified mature T cells (e.g., allodepleted T cells or pathogen-specific T cells). Others aim at accelerating de novo thymopoiesis from donor-derived hematopoietic stem cells in vivo via the administration of thymopoietic agents or the transfer of large numbers of T-cell precursors generated ex vivo. The present article will provide a brief summary of recent advances in the field of allodepletion and adoptive transfer of pathogen-specific T cells and a detailed discussion of strategies for enhancing thymopoiesis in vivo.

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Citations

Jul 11, 2012·The Journal of Experimental Medicine·Laetitia PeaudecerfBenedita Rocha
Apr 19, 2016·Immunological Reviews·Laetitia PeaudecerfBenedita Rocha
Sep 10, 2020·Frontiers in Immunology·Sinéad Kinsella, Jarrod A Dudakov

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Methods Mentioned

BETA
chemical castration

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