Advances in analysis of human milk oligosaccharides.

Advances in Nutrition
L Renee Ruhaak, Carlito B Lebrilla

Abstract

Oligosaccharides in human milk strongly influence the composition of the gut microflora of neonates. Because it is now clear that the microflora play important roles in the development of the infant immune system, human milk oligosaccharides (HMO) are studied frequently. Milk samples contain complex mixtures of HMO, usually comprising several isomeric structures that can be either linear or branched. Traditionally, HMO profiling was performed using HPLC with fluorescence or UV detection. By using porous graphitic carbon liquid chromatography MS, it is now possible to separate and identify most of the isomers, facilitating linkage-specific analysis. Matrix-assisted laser desorption ionization time-of-flight analysis allows fast profiling, but does not allow isomer separation. Novel MS fragmentation techniques have facilitated structural characterization of HMO that are present at lower concentrations. These techniques now facilitate more accurate studies of HMO consumption as well as Lewis blood group determinations.

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Citations

May 16, 2012·Advances in Nutrition·Sharon M DonovanRobert S Chapkin
May 16, 2012·Advances in Nutrition·Clemens KunzSharon M Donovan
Nov 20, 2013·Nutrition Reviews·Esther Castanys-MuñozPedro Antonio Prieto
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Nov 12, 2014·Annual Review of Animal Biosciences·Alline R PachecoDavid A Mills
Nov 1, 2016·Analytical and Bioanalytical Chemistry·Shiyue ZhouYehia Mechref
Nov 1, 2016·Analytical and Bioanalytical Chemistry·Jincui HuangCarlito B Lebrilla
Mar 10, 2015·Chromatographia·Kathrin StavenhagenManfred Wuhrer
Feb 19, 2017·Carbohydrate Research·Kelly M Craft, Steven D Townsend
Jul 23, 2014·Molecular & Cellular Proteomics : MCP·Ying YuDavid F Smith
Oct 21, 2017·Nutrition Reviews·Stephan ThurlBernd Stahl
Apr 3, 2015·The Journal of Nutrition·Linda C DuffyPamela Starke-Reed
Feb 13, 2020·Organic & Biomolecular Chemistry·Mithila D BandaraAlexei V Demchenko
Jan 24, 2016·Electrophoresis·Veronica MantovaniNicola Volpi
Apr 6, 2020·Glycobiology·Sara PorfirioParastoo Azadi
Jan 1, 2014·Supramolecular Chemistry·Nicole SerioMindy Levine
May 18, 2019·The Journal of Nutrition·Elisha GoonatillekeCarlito B Lebrilla
Jun 15, 2019·The British Journal of Nutrition·Andrea LeongHarsharn Gill
Jan 21, 2021·ACS Infectious Diseases·Rebecca E MooreSteven D Townsend
May 7, 2021·Food & Function·Stella A VerkhnyatskayaMarthe T C Walvoort
Sep 25, 2018·Journal of Agricultural and Food Chemistry·Dorota GarwolińskaWeronika Hewelt-Belka
Nov 7, 2021·Analytical and Bioanalytical Chemistry·Saeromi ChungDrew A Hall

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