Advances in anti-angiogenic agents for ovarian cancer treatment: The role of trebananib (AMG 386)

Critical Reviews in Oncology/hematology
Claudia MarchettiPierluigi Benedetti Panici

Abstract

Ovarian cancer is a multifaceted and genomically complex disease and has emerged as leading cause of death among gynecological malignancies. Gold-standard treatment consisted of cytoreductive surgery and paclitaxel-carboplatin chemotherapy. Recently, promising results of randomized trials have definitively confirmed the importance of angiogenesis in oncogenesis and ovarian cancer behavior, by showing a significant prolongation of progression-free survival with the addiction of an angiogenesis inhibitor to standard treatment in the first and second line setting. Research over the years has sequentially provided a rapidly broadening signaling landscape and many drugs targeting different signaling pathways of angiogenesis have been developed and investigated. Recently accumulating scientific evidence has started to shed light on the efficacy of AMG 386, a new peptibody reported to neutralize the interaction between angiopoietins (Ang1/2) and their Tie2 receptors, thus representing a promising alternative, both in terms of efficacy and toxicity profile and is considerably under investigation. The aim of this review is to summarize the recent researches and clinical progresses of AMG 386 as a novel target agent in ovarian cancer.

References

Oct 1, 1994·Biological & Pharmaceutical Bulletin·T OikawaS Omura
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·P LinK G Peters
Oct 17, 1998·Science·C SuriG D Yancopoulos
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·D M ValenzuelaG D Yancopoulos
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert E BristowF J Montz
Sep 4, 2003·Journal of the National Cancer Institute·Andreas du BoisUNKNOWN Arbeitsgemeinschaft Gynäkologische Onkologie Ovarian Cancer Study Group
Jun 14, 2005·Mayo Clinic Proceedings·Peter J TebbenRajiv Kumar
Jul 20, 2007·Molecular Cancer Research : MCR·Winston S N ShimPhilip E H Wong
Oct 3, 2007·The Journal of Clinical Investigation·Lars Johan NissenYihai Cao
Nov 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen A CannistraWilliam McGuire
Feb 13, 2008·Nature Clinical Practice. Oncology·Whitney A SpannuthRobert L Coleman
Apr 9, 2008·American Journal of Obstetrics and Gynecology·Chunhua LuAnil K Sood
Oct 22, 2008·Gynecologic Oncology·Robert E BristowDennis S Chi
Feb 25, 2009·Nature Reviews. Cancer·Timothy A YapStan B Kaye
Apr 22, 2009·Current Treatment Options in Oncology·Ernest S HanMark Wakabayashi
May 19, 2009·Angiogenesis·Markus Thomas, Hellmut G Augustin
Jun 24, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roy S HerbstLee S Rosen
May 27, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alain C MitaPatricia LoRusso
Jan 8, 2011·Expert Opinion on Investigational Drugs·Ewan Jd Robson, Prafull Ghatage
Nov 8, 2011·Critical Reviews in Oncology/hematology·Filippo BellatiMarianna Nuti
Dec 21, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Beth Y KarlanIgnace B Vergote
Dec 21, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tina Cascone, John V Heymach
Dec 30, 2011·The New England Journal of Medicine·Robert A BurgerUNKNOWN Gynecologic Oncology Group
Dec 30, 2011·The New England Journal of Medicine·Timothy J PerrenUNKNOWN ICON7 Investigators
May 28, 2013·Gynecologic Oncology·Bradley J MonkBeth Y Karlan
Aug 2, 2013·International Journal of Molecular Sciences·Nikos G GavalasAristotle Bamias
Aug 15, 2013·Current Opinion in Oncology·Danielle ShawGordon C Jayson
Jul 20, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I VergoteA Casado

❮ Previous
Next ❯

Citations

Jan 13, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ilary RuscitoPierluigi Benedetti Panici
Aug 16, 2016·SpringerPlus·Gonzalo H Giornelli
May 2, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Maria Luisa GasparriPierluigi Benedetti Panici
Jul 20, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ping YangZehua Wang
Feb 27, 2019·Current Oncology Reports·Jessica GillenKathleen Moore

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Related Papers

Critical Reviews in Oncology/hematology
Aristotelis BamiasE Pujade-Lauraine
Chemical Immunology and Allergy
Bamidele A AdesunloyeWilliam L Dahut
Expert Opinion on Investigational Drugs
Ewan Jd Robson, Prafull Ghatage
Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Lorenza Rimassa, Armando Santoro
© 2021 Meta ULC. All rights reserved