Advances in applying of multi-omics approaches in the research of systemic lupus erythematosus.

International Reviews of Immunology
Wencong SongYong Dai

Abstract

Systemic lupus erythematosus (SLE), an autoimmune disease that causes multiorgan injury, has an unclear etiology and complex pathogenesis. Numerous studies have found abnormal alterations in mRNAs, proteins and/or metabolites in SLE patients. These findings have extended our understanding of the pathogenesis of SLE. Novel omics techniques, such as transcriptome, proteome and metabolome profiling, can identify and quantify large numbers of biomarkers of human diseases. However, in most cases, biological reactions are the consequences of interactions among genes, proteomes, and metabolites. Single biomolecules or signaling pathways cannot fully explain biological traits or functions. Therefore, integrative multi-omics analysis can help us systematically comprehend the intrinsic molecular mechanisms underlying biological function and pathogenesis. Integrating transcriptome, proteome, and metabolome KEGG enrichment analysis data will expand our knowledge of the pathogenesis of SLE. This review discusses the application, research progress and outlook on integrative multi-omics analysis in SLE research.

References

Feb 7, 2003·Arthritis and Rheumatism·Xiaobo WangAnne Davidson
Oct 31, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Bruce Richardson
Dec 19, 2003·Arthritis Research & Therapy·Mary K Crow, Jay Wohlgemuth
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vasileios C KyttarisGeorge C Tsokos
Mar 6, 2007·Seminars in Nephrology·Volker VielhauerDetlef Schlöndorff
Aug 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Won-Woo LeeJörg J Goronzy
Oct 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qianjin LuBruce Richardson
Jan 22, 2008·Nature Genetics·UNKNOWN International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN)Jennifer A Kelly
Mar 4, 2009·Bioinformation·Siva Prasad AkulaSrinubabu Gedela
Dec 29, 2009·Autoimmunity Reviews·Andrea T BorchersM Eric Gershwin
Oct 15, 2010·Nature Biotechnology·Anna Portela, Manel Esteller
Jan 25, 2011·Rheumatology International·Man-Man LuDong-Qing Ye
Jun 2, 2011·BMC Biology·John H Malone, Brian Oliver
Oct 27, 2011·Journal of Biomedicine & Biotechnology·Kim Ohl, Klaus Tenbrock
Jun 12, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Honglei WangYong Dai
Jun 23, 2012·PloS One·Tianfu WuChandra Mohan
Oct 2, 2012·Current Opinion in Biotechnology·Kai-Oliver MutzFrank Stahl
Jan 11, 2013·Arthritis Research & Therapy·Aisha Lateef, Michelle Petri
Jan 4, 2013·PloS One·Xinzhou ZhangYong Dai
Oct 1, 2013·Cell·Daniel C KoboldtElaine R Mardis
May 27, 2014·International Journal of Clinical Rheumatology·Cristina Arriens, Chandra Mohan

❮ Previous
Next ❯

Citations

Jul 21, 2020·International Reviews of Immunology·Himanshu Kumar
Dec 15, 2020·Lupus·Luis Alonso GonzálezGraciela S Alarcón

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.