Advances in Biodetoxification of Ochratoxin A-A Review of the Past Five Decades

Frontiers in Microbiology
Wenying ChenXiao L Shen

Abstract

Ochratoxin A (OTA) is a toxic secondary fungal metabolite that widely takes place in various kinds of foodstuffs and feeds. Human beings and animals are inevitably threatened by OTA as a result. Therefore, it is necessary to adopt various measures to detoxify OTA-contaminated foods and feeds. Biological detoxification methods, with better safety, flavor, nutritional quality, organoleptic properties, availability, and cost-effectiveness, are more promising than physical and chemical detoxification methods. The state-of-the-art research advances of OTA biodetoxification by degradation, adsorption, or enzymes are reviewed in the present paper. Researchers have discovered a good deal of microorganisms that could degrade and/or adsorb OTA, including actinobacteria, bacteria, filamentous fungi, and yeast. The degradation of OTA to non-toxic or less toxic OTα via the hydrolysis of the amide bond is the most important OTA biodegradation mechanism. The most important influence factor of OTA adsorption capacity of microorganisms is cell wall components. A large number of microorganisms with good OTA degradation and/or adsorption ability, as well as some OTA degradation enzymes isolated or cloned from microorganisms and animal pancreas, h...Continue Reading

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Citations

Mar 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lin LiPeng Li
Jul 2, 2020·Toxins·Jianmei YuNona Mikiashvili
Mar 3, 2020·Frontiers in Microbiology·Walter P PflieglerTünde Pusztahelyi
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Aug 10, 2021·Frontiers in Microbiology·Xiaoyu XuBin Wang
Sep 6, 2020·Toxicon : Official Journal of the International Society on Toxinology·Pradeep KumarSukni Bui
Nov 18, 2021·Applied and Environmental Microbiology·Han LuoYu Zhou

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